Terameprocol (Synonyms: EM-1421)

Cat. No.: HY-10447 Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

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Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects.

For research use only. We do not sell to patients.

Terameprocol Chemical Structure

CAS No. : 24150-24-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4.54 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay	[PMID: 24080463]
A-375	IC₅₀	16.6 μM Compound: 1a, M4N	Cytotoxicity against human A375 cells after 5 days by MTT assay Cytotoxicity against human A375 cells after 5 days by MTT assay	[PMID: 19615898]
BXPC-3	GI₅₀	17.1 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 24080463]
C8166	CC₅₀	28.8 μM Compound: 21	Cytotoxicity against human C8166 cells by MTT assay Cytotoxicity against human C8166 cells by MTT assay	[PMID: 19413342]
HeLa	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 24080463]
Hep 3B2	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human Hep3B cells after 3 days by MTT assay Cytotoxicity against human Hep3B cells after 3 days by MTT assay	[PMID: 21123067]
HepG2	IC₅₀	44.5 μM Compound: 1a, M4N	Cytotoxicity against human HepG2 cells after 5 days by MTT assay Cytotoxicity against human HepG2 cells after 5 days by MTT assay	[PMID: 19615898]
HT-29	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human HT-29 cells after 3 days by MTT assay Cytotoxicity against human HT-29 cells after 3 days by MTT assay	[PMID: 21123067]
HT-29	IC₅₀	61.5 μM Compound: 1a, M4N	Cytotoxicity against human HT-29 cells after 5 days by MTT assay Cytotoxicity against human HT-29 cells after 5 days by MTT assay	[PMID: 19615898]
K562	IC₅₀	5.87 mg/L Compound: 2, EM-1421, M4N, Terameprocol	Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry	[PMID: 23434529]
LNCaP	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human LNCAP cells after 3 days by MTT assay Cytotoxicity against human LNCAP cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	42.4 μM Compound: 1a, M4N	Cytotoxicity against human MCF7 cells after 5 days by MTT assay Cytotoxicity against human MCF7 cells after 5 days by MTT assay	[PMID: 19615898]
NCI/ADR-RES	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay	[PMID: 21123067]
T47D	GI₅₀	5.36 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T47D cells after 72 hrs by MTT assay Cytotoxicity against human T47D cells after 72 hrs by MTT assay	[PMID: 24080463]
T98G	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T98G cells after 72 hrs by MTT assay Cytotoxicity against human T98G cells after 72 hrs by MTT assay	[PMID: 24080463]
U-87MG ATCC	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	[PMID: 24080463]

Clinical Trial

Molecular Weight

358.47

Formula

C₂₂H₃₀O₄

CAS No.

24150-24-1

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(C[C@H](C)[C@H](C)CC2=CC=C(OC)C(OC)=C2)=CC=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (278.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7896 mL	13.9482 mL	27.8963 mL
5 mM	0.5579 mL	2.7896 mL	5.5793 mL
10 mM	0.2790 mL	1.3948 mL	2.7896 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (269 KB) SDS (398 KB)

COA (245 KB) HNMR (239 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [Content Brief]

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [Content Brief]

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7896 mL	13.9482 mL	27.8963 mL	69.7408 mL
	5 mM	0.5579 mL	2.7896 mL	5.5793 mL	13.9482 mL
	10 mM	0.2790 mL	1.3948 mL	2.7896 mL	6.9741 mL
	15 mM	0.1860 mL	0.9299 mL	1.8598 mL	4.6494 mL
	20 mM	0.1395 mL	0.6974 mL	1.3948 mL	3.4870 mL
	25 mM	0.1116 mL	0.5579 mL	1.1159 mL	2.7896 mL
	30 mM	0.0930 mL	0.4649 mL	0.9299 mL	2.3247 mL
	40 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7435 mL
	50 mM	0.0558 mL	0.2790 mL	0.5579 mL	1.3948 mL
	60 mM	0.0465 mL	0.2325 mL	0.4649 mL	1.1623 mL
	80 mM	0.0349 mL	0.1744 mL	0.3487 mL	0.8718 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6974 mL

Terameprocol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terameprocol24150-24-1EM-1421EM1421EM 1421LipoxygenaseLOXInhibitorinhibitorinhibit

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Terameprocol (Synonyms: EM-1421)

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Terameprocol Related Antibodies

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•Related Small Molecules:

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Biological Activity

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References

Customer Review

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Complete Stock Solution Preparation Table

Terameprocol Related Classifications

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Your Recently Viewed Products:

Customer Review

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