2. Gene
  3. MTURN - maturin, neural progenitor differentiation regulator homolog Gene

MTURN - maturin, neural progenitor differentiation regulator homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Ells1; C7orf41

Gene ID: 222166 | Gene type: protein coding

About MTURN

This gene has 4 transcripts (splice variants) and 188 orthologues. Biased expression in brain (RPKM 152.3), fat (RPKM 61.0) and 8 other tissues.

Summary

Involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of MAPK cascade; and positive regulation of megakaryocyte differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MTURN Products(1)

mRNA Protein Name
NM_152793.3 NP_690006.2 maturin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
24681962 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24681962 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
24681962 GOA
involved in positive regulation of megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
24681962 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24681962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTURN Protein Structure

DUF4581

DUF4581: Domain of unknown function (DUF4581) (4 - 131)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

maturin

UPF0452 protein C7orf41

MTURN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MTURN Q8N3F0 SSX1 Homo sapiens Q16384
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 SSX1 Homo sapiens Q16384
Y2H Array
32296183
Intra MTURN Q8N3F0 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra MTURN Q8N3F0 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra MTURN Q8N3F0 TMEM239 Homo sapiens Q8WW34-2
Y2H Array
32296183
Intra MTURN Q8N3F0 TMEM239 Homo sapiens Q8WW34-2
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra MTURN Q8N3F0 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra MTURN Q8N3F0 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TNFRSF19 Homo sapiens Q9NS68-2
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TNFRSF19 Homo sapiens Q9NS68-2
Validated Y2H
32296183
Intra MTURN Q8N3F0 TNFRSF19 Homo sapiens Q9NS68-2
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM5 Homo sapiens Q9C035-3
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TRIM5 Homo sapiens Q9C035-3
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM5 Homo sapiens Q9C035-3
Validated Y2H
32296183
Intra MTURN Q8N3F0 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra MTURN Q8N3F0 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM38 Homo sapiens O00635
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM38 Homo sapiens O00635
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 ARRDC1 Homo sapiens Q8N5I2
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 ARRDC1 Homo sapiens Q8N5I2
Validated Y2H
32296183
Intra MTURN Q8N3F0 ARRDC1 Homo sapiens Q8N5I2
Y2H Array
32296183
Intra MTURN Q8N3F0 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra MTURN Q8N3F0 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra MTURN Q8N3F0 SUSD6 Homo sapiens Q92537
Y2H Array
32296183
Intra MTURN Q8N3F0 SUSD6 Homo sapiens Q92537
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 SUSD6 Homo sapiens Q92537
Validated Y2H
32296183
Intra MTURN Q8N3F0 AP2M1 Homo sapiens Q96CW1
Validated Y2H
32296183
Intra MTURN Q8N3F0 AP2M1 Homo sapiens Q96CW1
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 AP2M1 Homo sapiens Q96CW1
Y2H Array
32296183
Intra MTURN Q8N3F0 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra MTURN Q8N3F0 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 UBA52 Homo sapiens P62987
Y2H Array
32296183
Intra MTURN Q8N3F0 UBA52 Homo sapiens P62987
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 RPS27A Homo sapiens P62979
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 RPS27A Homo sapiens P62979
Y2H Array
32296183
Intra MTURN Q8N3F0 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra MTURN Q8N3F0 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra MTURN Q8N3F0 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra MTURN Q8N3F0 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra MTURN Q8N3F0 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
32296183
Intra MTURN Q8N3F0 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra MTURN Q8N3F0 PLEKHB2 Homo sapiens Q96CS7
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 UBB Homo sapiens P0CG47
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 UBB Homo sapiens P0CG47
Y2H Array
32296183
Intra MTURN Q8N3F0 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra MTURN Q8N3F0 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra MTURN Q8N3F0 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2

PKD2

Polycystic Kidney Disease, Adult, Type Ii

Apkd2

Polycystic Kidney Disease, Type 2

Adpkd2

Adult Polycystic Kidney Disease Type 2

Autosomal Dominant Polycystic Kidney Disease 2

Pkd-2

Polycystic Kidney Disease Adult Type Ii

Polycystic Kidney Type 2 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08825 MTURN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MTURN VGNC VGNC:102646
Mus musculus MTURN MGD MGI:1915485
Bos taurus MTURN VGNC VGNC:31755
Canis familiaris MTURN VGNC VGNC:54788
Rattus norvegicus MTURN RGD RGD:1549700
Macaca mulatta MTURN VGNC VGNC:75022