1. Gene
  2. Vegfa - vascular endothelial growth factor A Gene

Vegfa - vascular endothelial growth factor A Gene

Mus musculus

Also known as Vpf; Vegf

Gene ID: 22339 | Gene type: protein coding

About Vegfa

Summary

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]

Vegfa Products(10)

mRNA Protein Name
NM_001025250.3 NP_001020421.2 vascular endothelial growth factor A isoform 1
NM_001025257.3 NP_001020428.2 vascular endothelial growth factor A isoform 3
NM_001110266.1 NP_001103736.1 vascular endothelial growth factor A isoform 4 precursor
NM_001110267.1 NP_001103737.1 vascular endothelial growth factor A isoform 5 precursor
NM_001110268.1 NP_001103738.1 vascular endothelial growth factor A isoform 6 precursor
NM_001287056.1 NP_001273985.1 vascular endothelial growth factor A isoform 7 precursor
NM_001287057.1 NP_001273986.1 vascular endothelial growth factor A isoform Vegf-A precursor
NM_001287058.1 NP_001273987.1 vascular endothelial growth factor A isoform 9 precursor
NM_001317041.1 NP_001303970.1 vascular endothelial growth factor A isoform Vegf-Ax precursor
NM_009505.4 NP_033531.3 vascular endothelial growth factor A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chemoattractant activity IDA
IDA: Inferred from direct assay
21658587 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26503042 MGI
Biological Process GO Annotation Evidence Reference Source
involved in VEGF-activated neuropilin signaling pathway IDA
IDA: Inferred from direct assay
21828096 MGI
involved in VEGF-activated neuropilin signaling pathway IMP
IMP: Inferred from mutant phenotype
21658587 MGI
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
10617467 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
16778080 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12890722 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15073147 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
15927453 MGI
acts upstream of or within blood vessel morphogenesis IDA
IDA: Inferred from direct assay
15919073 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15919073 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16027358 MGI
acts upstream of or within bone trabecula formation IMP
IMP: Inferred from mutant phenotype
22886301 MGI
acts upstream of or within bone trabecula morphogenesis IMP
IMP: Inferred from mutant phenotype
22886301 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16251428 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
10229225 MGI
involved in cardiac vascular smooth muscle cell development IMP
IMP: Inferred from mutant phenotype
18093989 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
15601856 MGI
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
15601856 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
14722611 MGI
acts upstream of cell-cell adhesion IGI
IGI: Inferred from genetic interaction
24367707 MGI
involved in cellular response to vascular endothelial growth factor stimulus IGI
IGI: Inferred from genetic interaction
24401374 MGI
NOT involved in commissural neuron axon guidance IDA
IDA: Inferred from direct assay
21658587 MGI
involved in commissural neuron axon guidance IDA
IDA: Inferred from direct assay
21658587 MGI
involved in commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21658587 MGI
involved in coronary artery morphogenesis IMP
IMP: Inferred from mutant phenotype
18093989 MGI
involved in coronary vein morphogenesis IMP
IMP: Inferred from mutant phenotype
18093989 MGI
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
17215402 MGI
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24403062 MGI
acts upstream of or within endothelial cell proliferation IDA
IDA: Inferred from direct assay
31698979 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16251428 MGI
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15927453 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
16251428 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
22886301 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
17625068 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of or within lung vasculature development IMP
IMP: Inferred from mutant phenotype
11169844 MGI
involved in lymph vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
18093989 MGI
acts upstream of lymphangiogenesis IDA
IDA: Inferred from direct assay
20133819 MGI
acts upstream of or within lymphangiogenesis IGI
IGI: Inferred from genetic interaction
19233265 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
17625068 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
12890722 MGI
involved in motor neuron migration IMP
IMP: Inferred from mutant phenotype
26503042 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15073147 MGI
acts upstream of or within negative regulation of cell-cell adhesion IGI
IGI: Inferred from genetic interaction
24367707 MGI
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
23863481 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
21828096 MGI
acts upstream of or within negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22886301 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22886301 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
21828096 MGI
acts upstream of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
17215402 MGI
involved in neuron development IMP
IMP: Inferred from mutant phenotype
21828096 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
18093989 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
17050862 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
18772315 MGI
involved in positive chemotaxis IDA
IDA: Inferred from direct assay
21658587 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21828096 MGI
acts upstream of or within positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
20133819 MGI
NOT involved in positive regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
21658587 MGI
involved in positive regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
21658587 MGI
involved in positive regulation of axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
21658587 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
16291795 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17475663 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26683794 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15927453 MGI
acts upstream of or within positive regulation of lymphangiogenesis IDA
IDA: Inferred from direct assay
20133819 MGI
acts upstream of or within positive regulation of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
17215402 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22886301 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
18772315 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21828096 MGI
acts upstream of or within positive regulation of vascular permeability IDA
IDA: Inferred from direct assay
10617467 MGI
acts upstream of or within post-embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within primitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
14729577 MGI
acts upstream of or within regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
18772315 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation IDA
IDA: Inferred from direct assay
18772315 MGI
NOT involved in retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
21658587 MGI
involved in retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
21658587 MGI
involved in sprouting angiogenesis IDA
IDA: Inferred from direct assay
24401374 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
10229225 MGI
acts upstream of or within vasodilation IDA
IDA: Inferred from direct assay
31698979 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12975317 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12053176 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22886301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vascular endothelial growth factor A

vascular permeability factor

Recombinant Vegfa Proteins

Cat. No. Product Name Accession Purity
HY-P7312 VEGF164 Protein, Mouse Q00731-2 (A27-R190) ≥95%
HY-P7421 VEGF164 Protein, Mouse (P.pastoris) Q00731-2 (A27-R190) ≥95%
HY-P70761 VEGF164 Protein, Mouse (164a.a, P.pastoris) Q00731-2 (A27-R190) ≥95%
HY-P72775 VEGF120 Protein, Mouse Q00731-3 (A27-R146) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Vegfa NCBI NCBI:7422
Canis familiaris Vegfa NCBI NCBI:403802
Susscrofa domestica Vegfa NCBI
Leporidae Vegfa NCBI
Rattus norvegicus Vegfa NCBI NCBI:83785