Vegfa - vascular endothelial growth factor A Gene

Rattus norvegicus

Also known as VPF; Vegf; VEGF-A; VEGF111; VEGF164

Gene ID: 83785 | Gene type: protein coding

About Vegfa

Summary

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

Vegfa Products(13)

mRNA	Protein	Name
NM_001110333.2	NP_001103803.1	vascular endothelial growth factor A isoform 2
NM_001110334.2	NP_001103804.1	vascular endothelial growth factor A isoform 3
NM_001110335.1	NP_001103805.1	vascular endothelial growth factor A isoform 4
NM_001110336.1	NP_001103806.1	vascular endothelial growth factor A isoform 5
NM_001287107.1	NP_001274036.1	vascular endothelial growth factor A isoform 6 precursor
NM_001287108.1	NP_001274037.1	vascular endothelial growth factor A isoform Vegf-A precursor
NM_001287110.1	NP_001274039.1	vascular endothelial growth factor A isoform 8 precursor
NM_001287111.1	NP_001274040.1	vascular endothelial growth factor A isoform 9
NM_001287112.1	NP_001274041.1	vascular endothelial growth factor A isoform 10 precursor
NM_001287113.1	NP_001274042.1	vascular endothelial growth factor A isoform 11
NM_001287114.1	NP_001274043.1	vascular endothelial growth factor A isoform 12
NM_001317043.1	NP_001303972.1	vascular endothelial growth factor A isoform Vegf-Ax precursor
NM_031836.3	NP_114024.2	vascular endothelial growth factor A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity	IMP IMP: Inferred from mutant phenotype	23226762	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	12181492	RGD
enables growth factor binding	IPI IPI: Inferred from physical interaction	17881084	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	2320579	RGD
enables vascular endothelial growth factor receptor 2 binding	IMP IMP: Inferred from mutant phenotype	18614764	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in T-helper 1 type immune response	IDA IDA: Inferred from direct assay	15034080	RGD
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	16230500	RGD
involved in angiogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	11397779	RGD
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	16203926	RGD
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23226762	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	10215998	RGD
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	18617696	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19012730	RGD
involved in cellular response to wortmannin	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22326847	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	16959835	RGD
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	16230500	RGD
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	12881220	RGD
involved in negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	15312247	RGD
involved in negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	18614764	RGD
involved in nervous system development	IDA IDA: Inferred from direct assay	12181492	RGD
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17591953	RGD
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	23562340	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18614764	RGD
involved in positive regulation of signal transduction	IDA IDA: Inferred from direct assay	12483534	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	14693680	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12881220	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	16793871	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	16959835	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	8344219	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	17482424	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12881220	RGD
involved in response to oxygen levels	IEP IEP: Inferred from expression pattern	15885787	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	8344219	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	23106861	RGD
involved in tissue remodeling	IEP IEP: Inferred from expression pattern	23887904	RGD
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18614764	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	11940521	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	15034080	RGD
located in vesicle	IDA IDA: Inferred from direct assay	18758911	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vascular endothelial growth factor A

vascular permeability factor

Recombinant Vegfa Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7311	VEGF164 Protein, Rat (CHO)	P16612-2 (A27-R190)	≥95%
HY-P70638	VEGF164 Protein, Rat (P.pastoris)	P16612-2 (A27-R190, A36T)	≥95%
HY-P76122	VEGF164 Protein, Rat (sf9)	P16612-2 (A27-R190)	≥95%

Related Agents

Approval

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9906	Bevacizumab	Inhibitor	≥99.0%	Unkown
HY-P9906A	Bevacizumab (PBS)	Inhibitor	98.94%	Unkown
HY-P99116	Faricimab	Inhibitor	/	Unkown
HY-P9973	Brolucizumab	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-124593	PTC299	Inhibitor	99.89%	Phase 3
HY-B1788	Taurocholic acid		99.64%	Phase 2
HY-N0545	Taurocholic acid sodium	Agonist	≥98.0%	Phase 2

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99576	Tarcocimab	Inhibitor	98.35%	Phase 3
HY-P99476	ABP 215	Inhibitor	/	Phase 3
HY-P99330	Vanucizumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10799	EG00229 trifluoroacetate	Antagonist	98.18%	Unkown
HY-117661	SPHINX31	Inhibitor	99.13%	Unkown
HY-N2187	Deoxyshikonin		99.96%	Unkown
HY-115746	Dimethyl-bisphenol A	Inhibitor	99.78%	Unkown
HY-101931	hVEGF-IN-1	Inhibitor	99.26%	Unkown
HY-138647	TGP-377/421	Inhibitor	99.43%	Unkown
HY-124722	OHM1	Inhibitor	/	Unkown
HY-149886	HIF-2α-IN-9	Inhibitor	/	Unkown
HY-163760	ZM-32	Inhibitor	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-N0545R	Taurocholic acid (sodium) (Standard)	Agonist	/	Unkown
HY-P10550	VGB4	Antagonist	/	Unkown
HY-P3990	Coibamide A		/	Unkown
HY-RS15635	VEGFA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9951A	Ranibizumab (anti-VEGF)	Inhibitor	98.08%	Unkown
HY-P9920A	Ramucirumab (anti-VEGFR)	Antagonist	99.36%	Unkown
HY-P990689	Zifibancimig		/	Unkown
HY-P991033	Tovecimig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vegfa	NCBI	NCBI:7422
Canis familiaris	Vegfa	NCBI	NCBI:403802
Mus musculus	Vegfa	NCBI	NCBI:22339
Susscrofa domestica	Vegfa	NCBI
Leporidae	Vegfa	NCBI

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