FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr

Gene ID: 2268 | Gene type: protein coding

About FGR

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,612,064-27,635,185 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 32 paralogues. Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues.

Summary

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 Integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

FGR Products(3)

mRNA	Protein	Name
NM_001042729.2	NP_001036194.1	tyrosine-protein kinase Fgr
NM_001042747.2	NP_001036212.1	tyrosine-protein kinase Fgr
NM_005248.3	NP_005239.1	tyrosine-protein kinase Fgr

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Fc-gamma receptor I complex binding	IDA IDA: Inferred from direct assay	8327512	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8327512	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	10861086	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7519620	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	7519620	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7519620	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	10739672	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	2181286	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cytoskeleton	IDA IDA: Inferred from direct assay	8603737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGR Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Fgr

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

FGR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FGR	P09769	MET	Homo sapiens	P08581	FPS	24728074
Intra	FGR	P09769	KIT	Homo sapiens	P10721	FPS	24728074
Intra	FGR	P09769	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	FGR	P09769	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	FGR	P09769	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	FGR	P09769	AR	Homo sapiens	P10275	FPS	24728074
Intra	FGR	P09769	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	FGR	P09769	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Placental Insufficiency

Uteroplacental Vascular Insufficiency

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Cd45 Deficiency

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10230	Midostaurin		99.91%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10234	Saracatinib		99.92%	Phase 3
HY-15322	PRT062607	Inhibitor	97.13%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15141	Staurosporine		99.98%	Unkown
HY-112852	TL02-59		99.84%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-10234A	Saracatinib difumarate	Inhibitor	99.24%	Yes
HY-10230S	Midostaurin-d5	Inhibitor	≥98.0%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-112852A	TL02-59 dihydrochloride		/	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-RS04929	FGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FGR	VGNC	VGNC:40866
Bos taurus	FGR	VGNC	VGNC:28994
Mus musculus	FGR	MGD	MGI:95527
Rattus norvegicus	FGR	RGD	RGD:621319
Macaca mulatta	FGR	VGNC	VGNC:72658
Felis catus	FGR	VGNC	VGNC:62262
Others	FGR	NCBI

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