AAK1 - AP2 associated kinase 1 Gene

Homo sapiens

Gene ID: 22848 | Gene type: protein coding

About AAK1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,457,997-69,643,739 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 7.8), thyroid (RPKM 4.9) and 24 other tissues.

Summary

This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating Infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020]

AAK1 Products(3)

mRNA	Protein	Name
NM_001371577.1	NP_001358506.1	AP2-associated protein kinase 1 isoform 3
NM_014911.5	NP_055726.4	AP2-associated protein kinase 1 isoform 1
NM_001371575.1	NP_001358504.1	AP2-associated protein kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables AP-2 adaptor complex binding	IDA IDA: Inferred from direct assay	17494869	GOA
enables Notch binding	IDA IDA: Inferred from direct assay	21464124	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22645275	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	21464124	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17494869	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	21464124	GOA
involved in regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	18657069	GOA
involved in regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	17494869	GOA
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	18657069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AAK1 Protein Structure

Pkinase

0
200
400
600
800
961 a.a.

Protein Preferred Names

Protein Names

AP2-associated protein kinase 1

adaptor-associated kinase 1

Related Diseases

Diseases

Alias

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ehf
Ebola Fever	Ebola
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Critical Covid-19

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Cone-Rod Dystrophy 19

CORD19

Dystrophy, Cone-Rod, Type 19

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-134829	BMS-986176		98.79%	Phase 2

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117626	LP-935509	Inhibitor	99.74%	Unkown
HY-120179	LP-922761		98.21%	Unkown
HY-123940	SGC-AAK1-1		98.93%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-115868	BMS-911172		99.49%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-101290A	BMT-090605 hydrochloride	Inhibitor	99.09%	Unkown
HY-135871	BMT-124110		/	Unkown
HY-120179A	LP-922761 hydrate		≥98.0%	Unkown
HY-117453	BMS-901715		/	Unkown
HY-144301A	AAK1-IN-2 TFA		/	Unkown
HY-144302	AAK1-IN-3		/	Unkown
HY-145838	AAK1-IN-4		/	Unkown
HY-144302A	AAK1-IN-3 TFA		/	Unkown
HY-169405	AAK1/HDACs-IN-1	Inhibitor	/	Unkown
HY-161261	SARS-CoV-2-IN-81	Inhibitor	/	Unkown
HY-162388	TIM-098a	Inhibitor	/	Unkown
HY-144301	AAK1-IN-2		/	Unkown
HY-147083	SGC-AAK1-1N	Inhibitor	/	Unkown
HY-101290	BMT-090605	Inhibitor	/	Unkown
HY-145839	AAK1-IN-5		/	Unkown
HY-149054	GSK-3β inhibitor 13	Inhibitor	/	Unkown
HY-159879	AAK1-IN-6	Inhibitor	/	Unkown
HY-120092	BMT-046091	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AAK1	VGNC	VGNC:59451
Canis familiaris	AAK1	VGNC	VGNC:37410
Mus musculus	AAK1	MGD	MGI:1098687
Rattus norvegicus	AAK1	RGD	RGD:1305520
Macaca mulatta	AAK1	VGNC	VGNC:82094
Bos taurus	AAK1	VGNC	VGNC:25443
Others	AAK1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.