TCF25 - transcription factor 25 Gene

Homo sapiens

Also known as Hulp1; NULP1; FKSG26; PRO2620; hKIAA1049

Gene ID: 22980 | Gene type: protein coding

About TCF25

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,873,592-89,911,379 (from NCBI)

This gene has 26 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 33.1), testis (RPKM 28.8) and 25 other tissues.

Summary

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

TCF25 Products(1)

mRNA	Protein	Name
NM_014972.3	NP_055787.1	transcription factor 25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16574069	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16574069	GOA
involved in regulation of protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	30244831	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	30244831	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RQC complex	IDA IDA: Inferred from direct assay	30244831	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16574069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF25 Protein Structure

Tcf25

0
200
400
600
676 a.a.

Protein Preferred Names

Protein Names

transcription factor 25

TCF-25

TCF25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TCF25	Q9BQ70	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	TCF25	Q9BQ70	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	TCF25	Q9BQ70	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Anti Tag CoIP	33961781
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Anti Tag CoIP	28514442
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Anti Tag CoIP	35271311
Intra	TCF25	Q9BQ70	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	25416956
Intra	TCF25	Q9BQ70	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
Intra	TCF25	Q9BQ70	SAT1	Homo sapiens	P21673	Y2H	21516116
Intra	TCF25	Q9BQ70	SAT1	Homo sapiens	P21673	Y2H Array	25416956
Intra	TCF25	Q9BQ70	SAT1	Homo sapiens	P21673	Y2H Pooling	19060904
Intra	TCF25	Q9BQ70	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	TCF25	Q9BQ70	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	TCF25	Q9BQ70	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TCF25	Q9BQ70	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TCF25	Q9BQ70	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	TCF25	Q9BQ70	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	TCF25	Q9BQ70	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	TCF25	Q9BQ70	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	TCF25	Q9BQ70	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956
Intra	TCF25	Q9BQ70	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	TCF25	Q9BQ70	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	TCF25	Q9BQ70	GPX7	Homo sapiens	Q96SL4	Y2H Prey Pooling	32296183
Intra	TCF25	Q9BQ70	GPX7	Homo sapiens	Q96SL4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Vulvovaginitis

Vulvo-Vaginitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14305	TCF25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TCF25	VGNC	VGNC:66025
Mus musculus	TCF25	MGD	MGI:1914105
Macaca mulatta	TCF25	VGNC	VGNC:99607
Bos taurus	TCF25	VGNC	VGNC:35692
Canis familiaris	TCF25	VGNC	VGNC:47196
Rattus norvegicus	TCF25	RGD	RGD:1309054

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