RHOC - ras homolog family member C Gene

Homo sapiens

Also known as H9; ARH9; ARHC; RHOH9

Gene ID: 389 | Gene type: protein coding

About RHOC

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,701,131-112,707,408 (from NCBI)

This gene has 19 transcripts (splice variants), 257 orthologues and 22 paralogues. Ubiquitous expression in colon (RPKM 99.1), small intestine (RPKM 91.0) and 24 other tissues.

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RHOC Products(3)

mRNA	Protein	Name
NM_001042678.2	NP_001036143.1	rho-related GTP-binding protein RhoC precursor
NM_001042679.2	NP_001036144.1	rho-related GTP-binding protein RhoC precursor
NM_175744.5	NP_786886.1	rho-related GTP-binding protein RhoC precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apical junction assembly	IDA IDA: Inferred from direct assay	20974804	GOA
involved in mitotic cytokinesis	IDA IDA: Inferred from direct assay	16236794	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in positive regulation of lipase activity	IDA IDA: Inferred from direct assay	19887681	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20232393	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	16236794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOC Protein Structure

Ras

0
100
193 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoC

RAS-related homolog 9

RHOC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOC	P08134	RIPOR3	Homo sapiens	Q96MK2	Validated Y2H	32296183
Intra	RHOC	P08134	RIPOR2	Homo sapiens	Q9Y4F9	Y2H Prey Pooling	25416956
Intra	RHOC	P08134	DAAM1	Homo sapiens	Q9Y4D1	Anti Tag CoIP	33961781
Intra	RHOC	P08134	DIAPH1	Homo sapiens	O60610	Pull Down	18218625
Intra	RHOC	P08134	DIAPH1	Homo sapiens	O60610	Anti Tag CoIP	33961781
Intra	RHOC	P08134	ARHGAP1	Homo sapiens	Q07960	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

RHOC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80882	RhoA/B/C Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Inflammatory Breast Carcinoma

Inflammatory Breast Cancer	Inflammatory Carcinoma Of Breast
Mastitis Carcinomatosa	Breast Cancer, Inflammatory
Inflammatory Breast Neoplasms	Inflammatory Adenocarcinoma Of Breast

Breast Disease

Breast Diseases

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11950	RHOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHOC	RGD	RGD:1304965
Mus musculus	RHOC	MGD	MGI:106028
Bos taurus	RHOC	VGNC	VGNC:55672

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