GGA2 - golgi associated, gamma adaptin ear containing, ARF binding protein 2 Gene

Homo sapiens

Also known as VEAR

Gene ID: 23062 | Gene type: protein coding

About GGA2

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,463,542-23,524,359 (from NCBI)

This gene has 17 transcripts (splice variants), 207 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 28.0), thyroid (RPKM 15.2) and 25 other tissues.

Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

GGA2 Products(1)

mRNA	Protein	Name
NM_015044.4	NP_055859.1	ADP-ribosylation factor-binding protein GGA2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11821067	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	10749927	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	27901063	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	27901063	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10749927	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGA2 Protein Structure

VHS

GAT

Alpha_adaptinC2

0
100
200
300
400
500
613 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-binding protein GGA2

VHS domain and ear domain of gamma-adaptin

GGA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GGA2	Q9UJY4	MEMO1	Homo sapiens	Q9Y316	Validated Y2H	32296183
Intra	GGA2	Q9UJY4	SORL1	Homo sapiens	Q92673	Pull Down	11821067
Intra	GGA2	Q9UJY4	SORL1	Homo sapiens	Q92673	Validated Y2H	32814053
Intra	GGA2	Q9UJY4	SORL1	Homo sapiens	Q92673	Y2H Array	32814053
Intra	GGA2	Q9UJY4	SORL1	Homo sapiens	Q92673	Y2H	11821067
Intra	GGA2	Q9UJY4	SORL1	Homo sapiens	Q92673	Y2H Pooling	32814053
Intra	GGA2	Q9UJY4	BACE1	Homo sapiens	P56817	Anti Tag CoIP	26053850
Intra	GGA2	Q9UJY4	RABEP1	Homo sapiens	Q15276	Y2H	12505986
Intra	GGA2	Q9UJY4	RABEP1	Homo sapiens	Q15276	Anti Tag CoIP	12505986
Intra	GGA2	Q9UJY4	RABEP1	Homo sapiens	Q15276	Pull Down	10747088
Intra	GGA2	Q9UJY4	RABEP1	Homo sapiens	Q15276	Anti Tag CoIP	28514442
Intra	GGA2	Q9UJY4	RABEP1	Homo sapiens	Q15276	Anti Tag CoIP	33961781
Intra	GGA2	Q9UJY4	GGA1	Homo sapiens	Q9UJY5	Anti Tag CoIP	33961781
Intra	GGA2	Q9UJY4	GGA1	Homo sapiens	Q9UJY5	Anti Tag CoIP	28514442
Intra	GGA2	Q9UJY4	GGA1	Homo sapiens	Q9UJY5	Pull Down	14638859
Intra	GGA2	Q9UJY4	GGA3	Homo sapiens	Q9NZ52	Pull Down	14638859
Intra	GGA2	Q9UJY4	CA8	Homo sapiens	P35219	Y2H Array	25416956
Intra	GGA2	Q9UJY4	SPG21	Homo sapiens	Q9NZD8	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05394	GGA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GGA2	VGNC	VGNC:29336
Mus musculus	GGA2	MGD	MGI:1921355
Rattus norvegicus	GGA2	RGD	RGD:1304800
Macaca mulatta	GGA2	VGNC	VGNC:72728
Felis catus	GGA2	VGNC	VGNC:62533
Canis familiaris	GGA2	VGNC	VGNC:41194

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