GGA3 - golgi associated, gamma adaptin ear containing, ARF binding protein 3 Gene

Homo sapiens

Gene ID: 23163 | Gene type: protein coding

About GGA3

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,223,728-75,262,363 (from NCBI)

This gene has 24 transcripts (splice variants), 279 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 11.9), lymph node (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

GGA3 Products(6)

mRNA	Protein	Name
NM_001172703.3	NP_001166174.1	ADP-ribosylation factor-binding protein GGA3 isoform 1
NM_001172704.3	NP_001166175.1	ADP-ribosylation factor-binding protein GGA3 isoform 2
NM_001291641.2	NP_001278570.1	ADP-ribosylation factor-binding protein GGA3 isoform 1
NM_001291642.2	NP_001278571.1	ADP-ribosylation factor-binding protein GGA3 isoform 3
NM_014001.5	NP_054720.1	ADP-ribosylation factor-binding protein GGA3 isoform short
NM_138619.4	NP_619525.1	ADP-ribosylation factor-binding protein GGA3 isoform long

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11387475	GOA
enables protein transporter activity	IDA IDA: Inferred from direct assay	17116753	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17116753	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	10749927	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	17116753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	27901063	GOA
involved in negative regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	17553422	GOA
involved in protein destabilization	IDA IDA: Inferred from direct assay	20484053	GOA
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	27901063	GOA
involved in protein targeting to lysosome	IPI IPI: Inferred from physical interaction	17116753	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	17553422	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosome	IDA IDA: Inferred from direct assay	17116753	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17116753	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10749927	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGA3 Protein Structure

VHS

0
100
153 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-binding protein GGA3

Golgi-localized, gamma ear-containing, ARF-binding protein 3

GGA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GGA3	Q9NZ52	IGF2R	Homo sapiens	P11717	Imaging	16977309
Intra	GGA3	Q9NZ52	IGF2R	Homo sapiens	P11717	FPS	37100772
Intra	GGA3	Q9NZ52	PTGDR	Homo sapiens	Q13258	Anti Bait CoIP	32334026
Intra	GGA3	Q9NZ52	PTGDR	Homo sapiens	Q13258	IF	32334026
Intra	GGA3	Q9NZ52	PTGDR	Homo sapiens	Q13258	Anti Tag CoIP	32334026
Intra	GGA3	Q9NZ52	BACE1	Homo sapiens	P56817	Anti Tag CoIP	26053850
Intra	GGA3	Q9NZ52	PACS1	Homo sapiens	Q6VY07	Pull Down	16977309
Intra	GGA3	Q9NZ52	PACS1	Homo sapiens	Q6VY07	Anti Tag CoIP	16977309
Intra	GGA3	Q9NZ52	M6PR	Homo sapiens	P20645	FPS	37100772
Intra	GGA3	Q9NZ52	M6PR	Homo sapiens	P20645	Y2H	11387475
Intra	GGA3	Q9NZ52	RABEP1	Homo sapiens	Q15276	Y2H	12505986
Intra	GGA3	Q9NZ52	RABEP1	Homo sapiens	Q15276	Anti Tag CoIP	12505986
Intra	GGA3	Q9NZ52	RABEP1	Homo sapiens	Q15276	FPS	37100772
Intra	GGA3	Q9NZ52	GGA1	Homo sapiens	Q9UJY5	Pull Down	14638859
Intra	GGA3	Q9NZ52	GGA2	Homo sapiens	Q9UJY4	EM	14638859
Intra	GGA3	Q9NZ52	GGA2	Homo sapiens	Q9UJY4	Pull Down	14638859
Intra	GGA3	Q9NZ52	ARF6	Homo sapiens	P62330	Pull Down	24056087
Intra	GGA3	Q9NZ52	ARF6	Homo sapiens	P62330	Pull Down	23143332
Cross	GGA3	Q9NZ52	NP	Zaire ebolavirus	P18272	FPS	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 17

NPHS17	Nephrotic Syndrome Type 17
Nephrotic Syndrome 17

Dyschromatosis Universalis Hereditaria

Duh

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05395	GGA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GGA3	VGNC	VGNC:41195
Rattus norvegicus	GGA3	RGD	RGD:1309553
Bos taurus	GGA3	VGNC	VGNC:29337
Felis catus	GGA3	VGNC	VGNC:62534
Macaca mulatta	GGA3	VGNC	VGNC:72733
Mus musculus	GGA3	MGD	MGI:2384159

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