TNRC6B - trinucleotide repeat containing adaptor 6B Gene

Homo sapiens

Also known as GDSBA

Gene ID: 23112 | Gene type: protein coding

About TNRC6B

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,044,834-40,335,808 (from NCBI)

This gene has 9 transcripts (splice variants), 293 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 3.9), thyroid (RPKM 2.3) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2022]

TNRC6B Products(3)

mRNA	Protein	Name
NM_001024843.2	NP_001020014.1	trinucleotide repeat-containing gene 6B protein isoform 3
NM_001162501.2	NP_001155973.1	trinucleotide repeat-containing gene 6B protein isoform 1
NM_015088.3	NP_055903.2	trinucleotide repeat-containing gene 6B protein isoform 2

TNRC6B Protein Structure

Ago_hook

RRM_5

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1200
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1833 a.a.

Protein Preferred Names

Protein Names

trinucleotide repeat-containing gene 6B protein

trinucleotide repeat containing 6B

TNRC6B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNRC6B	Q9UPQ9	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	21981923
Intra	TNRC6B	Q9UPQ9	CNOT1	Homo sapiens	A5YKK6	Pull Down	21981923
Intra	TNRC6B	Q9UPQ9	PAN3	Homo sapiens	Q58A45	Pull Down	21981923
Intra	TNRC6B	Q9UPQ9	AGO2	Homo sapiens	Q9UKV8	Pull Down	24043833
Intra	TNRC6B	Q9UPQ9	AGO2	Homo sapiens	Q9UKV8	Crosslink	24043833
Intra	TNRC6B	Q9UPQ9	AGO2	Homo sapiens	Q9UKV8	Peptide Array	24043833
Intra	TNRC6B	Q9UPQ9	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	24043833
Intra	TNRC6B	Q9UPQ9	AGO2	Homo sapiens	Q9UKV8	NMR	24043833
Intra	TNRC6B	Q9UPQ9	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	21063388
Intra	TNRC6B	Q9UPQ9	PABPC1	Homo sapiens	P11940	Pull Down	21981923
Cross	TNRC6B	Q9UPQ9	pAbp	Drosophila melanogaster	P21187	Anti Tag CoIP	21063388

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Global Developmental Delay With Speech And Behavioral Abnormalities

GDSBA

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Subserous Uterine Fibroid

Subserous Leiomyoma Of Uterus

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14865	TNRC6B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNRC6B	VGNC	VGNC:36205
Macaca mulatta	TNRC6B	VGNC	VGNC:79786
Felis catus	TNRC6B	VGNC	VGNC:66434
Rattus norvegicus	TNRC6B	RGD	RGD:621428
Canis familiaris	TNRC6B	VGNC	VGNC:82302
Mus musculus	TNRC6B	MGD	MGI:2443730

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