CNOT1 - CCR4-NOT transcription complex subunit 1 Gene

Homo sapiens

Also known as NOT1; CDC39; HPE12; NOT1H; VIBOS; AD-005

Gene ID: 23019 | Gene type: protein coding

About CNOT1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,519,951-58,629,826 (from NCBI)

This gene has 22 transcripts (splice variants), 215 orthologues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022]

CNOT1 Products(3)

mRNA	Protein	Name
NM_001265612.2	NP_001252541.1	CCR4-NOT transcription complex subunit 1 isoform c
NM_016284.5	NP_057368.3	CCR4-NOT transcription complex subunit 1 isoform a
NM_206999.3	NP_996882.1	CCR4-NOT transcription complex subunit 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	24768540	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	22977175	GOA
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	16778766	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	16778766	GOA
contributes to poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	21976065	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10637334	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24768540	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	23172285	GOA
involved in negative regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	24736845	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IDA IDA: Inferred from direct assay	21976065	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	22977175	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	23644599	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	22367759	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in P-body	IDA IDA: Inferred from direct assay	21976065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT1 Protein Structure

DUF3819

Not1

0
400
800
1200
1600
2000
2376 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 1

CCR4-associated factor 1

CNOT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	17452450
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	21278420
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	X-Ray Diffraction	22977175
Intra	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Pull Down	30833792
Intra	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Confocal	30833792
Intra	CNOT1	A5YKK6	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	21981923
Intra	CNOT1	A5YKK6	CNOT11	Homo sapiens	Q9UKZ1	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0-1	Anti Tag CoIP	23463101
Cross	CNOT1	A5YKK6	Zfp36	Mus musculus	P22893	Anti Tag CoIP	21278420
Intra	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	18377426
Intra	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Pull Down	22977175
Intra	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TNRC6B	Homo sapiens	Q9UPQ9	Pull Down	21981923

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Holoprosencephaly 12 With Or Without Pancreatic Agenesis

HPE12	Holoprosencephaly 12, With Or Without Pancreatic Agenesis
Pancreatic Agenesis-Holoprosencephaly Syndrome

Vissers-Bodmer Syndrome

VIBOS

Alopecia-Intellectual Disability Syndrome 4

Alopecia-Mental Retardation Syndrome 4

APMR4

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Spermatogenic Failure 11

SPGF11

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02899	CNOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNOT1	VGNC	VGNC:71386
Felis catus	CNOT1	VGNC	VGNC:68516
Bos taurus	CNOT1	VGNC	VGNC:27514
Rattus norvegicus	CNOT1	RGD	RGD:1308009
Mus musculus	CNOT1	MGD	MGI:2442402
Canis familiaris	CNOT1	VGNC	VGNC:39410

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