CEP68 - centrosomal protein 68 Gene

Homo sapiens

Also known as KIAA0582

Gene ID: 23177 | Gene type: protein coding

About CEP68

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,056,416-65,087,004 (from NCBI)

This gene has 31 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 8.3), ovary (RPKM 8.1) and 25 other tissues.

Summary

Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CEP68 Products(4)

mRNA	Protein	Name
NM_001319100.2	NP_001306029.1	centrosomal protein of 68 kDa isoform a
NM_001319101.2	NP_001306030.1	centrosomal protein of 68 kDa isoform b
NM_001410838.1	NP_001397767.1	centrosomal protein of 68 kDa isoform c
NM_015147.3	NP_055962.2	centrosomal protein of 68 kDa isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24554434	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24554434	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centriole-centriole cohesion	IMP IMP: Inferred from mutant phenotype	24554434	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	18042621	GOA
involved in protein localization to organelle	IMP IMP: Inferred from mutant phenotype	24554434	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	18042621	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centrosomal protein of 68 kDa

centrosomal protein 68kDa

CEP68 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP68	Q76N32	CTBP1	Homo sapiens	Q13363-2	Validated Y2H	25416956
Intra	CEP68	Q76N32	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	25503564
Intra	CEP68	Q76N32	CDK5RAP2	Homo sapiens	Q96SN8	Anti Bait CoIP	25503564
Intra	CEP68	Q76N32	CDK5RAP2	Homo sapiens	Q96SN8	Anti Tag CoIP	25503564
Intra	CEP68	Q76N32	PLK1	Homo sapiens	P53350	Protein Kinase Assay	25503564
Intra	CEP68	Q76N32	PLK1	Homo sapiens	P53350	Anti Tag CoIP	25503564
Intra	CEP68	Q76N32	PCNT	Homo sapiens	O95613	Anti Tag CoIP	25503564
Intra	CEP68	Q76N32	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	CEP68	Q76N32	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	CEP68	Q76N32	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02520	CEP68 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CEP68	MGD	MGI:2667663
Bos taurus	CEP68	VGNC	VGNC:27210
Felis catus	CEP68	VGNC	VGNC:60780
Macaca mulatta	CEP68	VGNC	VGNC:71127
Canis familiaris	CEP68	VGNC	VGNC:39134
Rattus norvegicus	CEP68	RGD	RGD:1309101

Name
Email *

	Sorry, but the email address you supplied was invalid.