2. Gene
  3. DIP2A - disco interacting protein 2 homolog A Gene

DIP2A - disco interacting protein 2 homolog A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DIP2; C21orf106

Gene ID: 23181 | Gene type: protein coding

About DIP2A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,458,891-46,583,871 (from NCBI)

This gene has 13 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 7.3), prostate (RPKM 6.1) and 25 other tissues.

Summary

The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

DIP2A Products(10)

mRNA Protein Name
NM_001146115.2 NP_001139587.1 disco-interacting protein 2 homolog A isoform f
NM_001146116.2 NP_001139588.1 disco-interacting protein 2 homolog A isoform g
NM_001353942.2 NP_001340871.1 disco-interacting protein 2 homolog A isoform h
NM_001353943.2 NP_001340872.1 disco-interacting protein 2 homolog A isoform a
NM_001353944.2 NP_001340873.1 disco-interacting protein 2 homolog A isoform i
NM_001410751.1 NP_001397680.1 disco-interacting protein 2 homolog A isoform j
NM_015151.4 NP_055966.2 disco-interacting protein 2 homolog A isoform a
NM_206889.3 NP_996772.1 disco-interacting protein 2 homolog A isoform b
NM_206890.3 NP_996773.1 disco-interacting protein 2 homolog A isoform c
NM_206891.3 NP_996774.1 disco-interacting protein 2 homolog A isoform d
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20054002 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
20860622 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
20054002 GOA
located in membrane IDA
IDA: Inferred from direct assay
20054002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIP2A Protein Structure

DMAP_binding

DMAP_binding: DMAP1-binding Domain (10 - 122)

AMP-binding

AMP-binding: AMP-binding enzyme (341 - 813)

AMP-binding

AMP-binding: AMP-binding enzyme (992 - 1437)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1571 a.a.
Protein Preferred Names Protein Names

disco-interacting protein 2 homolog A

DIP2 disco-interacting protein 2 homolog A

DIP2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DIP2A Q14689 FST Homo sapiens P19883
Competition Binding
20860622
Intra
DIP2A Q14689 FSTL1 Homo sapiens Q12841
Y2H
20860622
Cross
DIP2A Q14689 Fstl1 Mus musculus Q62356
Anti Tag CoIP
20054002
Intra
DIP2A Q14689 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
DIP2A Q14689 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
DIP2A Q14689 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Intra
DIP2A Q14689 GPATCH2L Homo sapiens Q9NWQ4
Y2H Prey Pooling
25416956
Intra
DIP2A Q14689 GPATCH2L Homo sapiens Q9NWQ4
Y2H Array
25416956
Intra
DIP2A Q14689 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
DIP2A Q14689 ATOSB Homo sapiens Q7L5A3
Y2H Prey Pooling
25416956
Intra
DIP2A Q14689 ATOSB Homo sapiens Q7L5A3
Validated Y2H
25416956
Intra
DIP2A Q14689 ATOSB Homo sapiens Q7L5A3
Y2H Array
25416956
Intra
DIP2A Q14689 TGFB1 Homo sapiens P01137
SPR
20860622
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Histiocytic Disease

Histiocytic Disorders, Malignant
Dyslexia
Hermansky-Pudlak Syndrome 5

HPS5

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 5

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder
Middle Cerebral Artery Infarction

Infarction, Middle Cerebral Artery

Infarction Middle Cerebral Artery
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03772 DIP2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DIP2A VGNC VGNC:28066
Macaca mulatta DIP2A VGNC VGNC:71641
Felis catus DIP2A VGNC VGNC:61492
Rattus norvegicus DIP2A RGD RGD:1582897
Mus musculus DIP2A MGD MGI:2385920