2. Gene
  3. FPR1 - formyl peptide receptor 1 Gene

FPR1 - formyl peptide receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FPR; FMLP

Gene ID: 2357 | Gene type: protein coding

About FPR1

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,745,172-51,751,878 (from NCBI)

This gene has 4 transcripts (splice variants), 96 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues.

Summary

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by Microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

FPR1 Products(2)

mRNA Protein Name
NM_001193306.2 NP_001180235.1 fMet-Leu-Phe receptor
NM_002029.4 NP_002020.1 fMet-Leu-Phe receptor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
15210802 GOA
enables G protein-coupled receptor binding IDA
IDA: Inferred from direct assay
10823817 GOA
enables N-formyl peptide receptor activity IDA
IDA: Inferred from direct assay
12218158 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22447027 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22859307 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FPR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (43 - 301)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

fMet-Leu-Phe receptor

N-formylpeptide chemoattractant receptor

FPR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FPR1 P21462 MAPK13 Homo sapiens O15264
Anti Tag CoIP
22447027
Intra
FPR1 P21462 GRK2 Homo sapiens P25098
Anti Tag CoIP
22447027
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Susceptibility To Localized Juvenile Periodontitis
Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Aggressive Periodontitis

Juvenile Periodontitis

Periodontitis, Juvenile

Prepubertal Periodontitis
Periodontitis, Aggressive, 1

Pustulosis Palmaris Et Plantaris

Ppp

Periodontitis, Juvenile

Localized Pustular Psoriasis

Jpd

Periodontitis 1, Juvenile

Lpp

Palmoplantar Pustulosis

Prepubertal Periodontitis

Periodontitis, Aggressive 1

Periodontitis, Prepubertal

Periodontititis, Aggressive, 1

AP1

Juvenile Periodontitis

Periodontitis Juvenile

Pustulosis Of Palms And Soles

Generalized Pustular Psoriasis
Diamond-Blackfan Anemia 2

DBA2

Anemia, Diamond-Blackfan, 2

Anemia Diamond-Blackfan 2
Pulmonary Coin Lesion

Coin Lesion Of Lung

Solitary Pulmonary Nodule

Coin Lesion Lung
Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease
Anaerobic Meningitis
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Rubeosis Iridis
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1122 Cyclosporin H 99.43% Unkown
HY-101283 HCH6-1 99.14% Unkown
HY-103286 PD176252 Antagonist 99.38% Unkown
HY-P1795 Boc-FLFLF 98.02% Unkown
HY-116216 PD 168368 Antagonist ≥99.0% Unkown
HY-P1121A WKYMVM-NH2 TFA 99.67% Unkown
HY-19574 FPR Agonist 43 99.79% Unkown
HY-128113 AG-09/1 99.79% Unkown
HY-P1116A PBP10 TFA Inhibitor 98.14% Unkown
HY-156293 FPR1 antagonist 1 ≥95.0% Unkown
HY-N8152 Randialic acid B Inhibitor 99.94% Unkown
HY-144604 FPR2 agonist 2 Agonist 99.59% Unkown
HY-P1117 MMK1 99.22% Unkown
HY-P1744 N-Formyl-Met-Leu-Phe-Lys 98.98% Unkown
HY-P1118 Ac9-25 98.54% Unkown
HY-P10738A N-Formyl-MMYALF TFA Inhibitor / Unkown
HY-117971 BVT173187 / Unkown
HY-156294 FPR1 antagonist 2 / Unkown
HY-P10724 fMIFL Agonist / Unkown
HY-P10738 N-Formyl-MMYALF Inhibitor / Unkown
HY-P1116 PBP10 Inhibitor / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-P1118A Ac9-25 TFA / Unkown
HY-RS05085 FPR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FPR1 VGNC VGNC:109505
Rattus norvegicus FPR1 RGD RGD:1310883
Mus musculus FPR1 MGD MGI:107443