Malt1 - MALT1 paracaspase Gene

Mus musculus

Also known as Pcasp1; A630046N12; D430033E09Rik

Gene ID: 240354 | Gene type: protein coding

About Malt1

Chromosome 18: 65,564,009-65,612,138 forward strand.GRCm39:CM001011.3

This gene has 13 transcripts (splice variants), 197 orthologues and is associated with 14 phenotypes. Ubiquitous expression in spleen adult (RPKM 11.3), mammary gland adult (RPKM 4.9) and 27 other tissues.

Summary

Enables protease binding activity. Involved in lipopolysaccharide-mediated signaling pathway; positive regulation of immune response; and proteolysis. Acts upstream of or within several processes, including B-1 B cell differentiation; cellular response to lipopolysaccharide; and positive regulation of NF-kappaB transcription factor activity. Located in cytosol. Part of polkadots. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]

Malt1 Products(2)

mRNA	Protein	Name
NM_001365019.1	NP_001351948.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 2
NM_172833.3	NP_766421.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	18223652	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16495340	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell activation	IMP IMP: Inferred from mutant phenotype	14576442	MGI
acts upstream of or within B-1 B cell differentiation	IMP IMP: Inferred from mutant phenotype	14614861	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	14576442	MGI
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	25282160	MGI
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	16831874	MGI
involved in innate immune response	IEP IEP: Inferred from expression pattern	16831874	MGI
involved in lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	16831874	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	14614861	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	14614861	MGI
involved in positive regulation of T-helper 17 cell differentiation	IDA IDA: Inferred from direct assay	25282160	MGI
involved in proteolysis	IDA IDA: Inferred from direct assay	25282160	MGI
acts upstream of or within regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14614861	MGI
acts upstream of or within response to fungus	IMP IMP: Inferred from mutant phenotype	16862125	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16831874	MGI
part of polkadots	IDA IDA: Inferred from direct assay	16495340	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Malt1 Protein Structure

Death_MALT1

Ig_3

Peptidase_C14

MALT1_Ig

0
200
400
600
821 a.a.

Protein Preferred Names

Protein Names

mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

mucosa associated lymphoid tissue lymphoma translocation gene 1

paracaspase-1

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 1
HY-139399	Safimaltib	Inhibitor	99.63%	Phase 1
HY-160698	SGR-1505	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect Inhibitor	Purity	Rare Diseases Unkown
HY-12276	MALT1 inhibitor MI-2	Inhibitor	99.95%	Unkown
HY-115466	MLT-748	Inhibitor	99.89%	Unkown
HY-121282	Mepazine	Inhibitor	99.91%	Unkown
HY-121282A	Mepazine hydrochloride	Inhibitor	99.94%	Unkown
HY-134820	MLT-943	Inhibitor	99.77%	Unkown
HY-142648	MLT-985	Inhibitor	99.34%	Unkown
HY-P1407	Z-VRPR-FMK TFA	Inhibitor	95.92%	Unkown
HY-124587	MLT-747	Inhibitor	99.56%	Unkown
HY-131902	MLT-231	Inhibitor	99.55%	Unkown
HY-121282B	Mepazine acetate	Inhibitor	/	Unkown
HY-150232	MALT1-IN-11	Inhibitor	/	Unkown
HY-143427	MALT1-IN-9	Inhibitor	/	Unkown
HY-143426	MALT1-IN-8	Inhibitor	/	Unkown
HY-151805	RGT-068A	Inhibitor	/	Unkown
HY-143425A	(R)-MALT1-IN-7	Inhibitor	/	Unkown
HY-143424	MALT1-IN-6	Inhibitor	/	Unkown
HY-143423A	(S)-MALT1-IN-5	Inhibitor	/	Unkown
HY-162268	MALT1-IN-13	Inhibitor	/	Unkown
HY-164560	MALT1-IN-14	Inhibitor	/	Unkown
HY-120231	Z-VRPR-FMK	Inhibitor	/	Unkown
HY-143422	MALT1-IN-3	Inhibitor	/	Unkown
HY-143425	MALT1-IN-7	Inhibitor	/	Unkown
HY-P4544	Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone	Inhibitor	/	Unkown
HY-143423	MALT1-IN-5	Inhibitor	/	Unkown
HY-148249	NVS-MALT1	Inhibitor	/	Unkown
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	Unkown
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Malt1	NCBI	NCBI:10892

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