Gip - gastric inhibitory polypeptide Gene

Rattus norvegicus

Also known as Gludins; RATGLUDINS

Gene ID: 25040 | Gene type: protein coding

About Gip

Summary

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of glucose transmembrane transport; and triglyceride homeostasis. Located in cytoplasm; extracellular space; and neuronal cell body. Used to study type 2 diabetes mellitus. Biomarker of hyperinsulinism; hypothyroidism; obesity; and pancreas disease. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human GIP (gastric inhibitory polypeptide). [provided by Alliance of Genome Resources, Apr 2022]

Gip Products(1)

mRNA	Protein	Name
NM_019630.3	NP_062604.1	gastric inhibitory polypeptide precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables signaling receptor binding	IMP IMP: Inferred from mutant phenotype	8958204	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in digestive system development	IEP IEP: Inferred from expression pattern	8674860	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	7716131	RGD
involved in long-term synaptic potentiation	IDA IDA: Inferred from direct assay	18234983	RGD
involved in positive regulation of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	8843773	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	8958204	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	8958204	RGD
involved in positive regulation of synaptic transmission	IDA IDA: Inferred from direct assay	18234983	RGD
involved in response to acidic pH	IMP IMP: Inferred from mutant phenotype	34554	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	6376308	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	19170165	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	18685191	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	8931636	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	19520739	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19056762	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	6753106	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	7937351	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	11950233	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	7599968	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16402076	RGD
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	1816061	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19520739	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19170165	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gastric inhibitory polypeptide

Glucose-dependent insulinotropic peptide

glucose-dependent insulinotropic polypeptide

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-E70397	Dipeptidyl peptidase IV	Inhibitor	/	Phase 4
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	99.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0276	GIP, human	Agonist	99.72%	Unkown
HY-P2542	GIP (3-42), human	Antagonist	99.98%	Unkown
HY-P10138	human GIP(3-30), amide	Antagonist	98.82%	Unkown
HY-P10138A	human GIP(3-30), amide TFA	Antagonist	98.82%	Unkown
HY-P0276A	GIP, human TFA	Agonist	99.88%	Unkown
HY-P2080B	GIP (1-30) amide,human acetate	Agonist	98.24%	Unkown
HY-P3247	[D-Ala2]-GIP (human)	Agonist	98.56%	Unkown
HY-P3579	Gastric Inhibitory Peptide, porcine		99.67%	Unkown
HY-P3584A	(Pro3) GIP, human TFA		99.79%	Unkown
HY-P10735	GIP (mouse)	Activator	99.76%	Unkown
HY-P2541A	GIP (1-30) amide, porcine TFA	Agonist	99.95%	Unkown
HY-164535	Maridebart cafraglutide	Agonist	/	Unkown
HY-P3580A	Acetyl Gastric Inhibitory Peptide (human) (TFA)		99.70%	Unkown
HY-P10302A	GLP-1R/GIPR agonist-1 (soduim)	Agonist	96.55%	Unkown
HY-P1434	[Pro3]-GIP (mouse)	Antagonist	98.87%	Unkown
HY-P10302	GLP-1R/GIPR agonist-1	Agonist	/	Unkown
HY-P2080C	GIP (1-30)-Myr	Agonist	/	Unkown
HY-P3255	DA-JC4	Agonist	/	Unkown
HY-P3584	(Pro3) GIP, human	Agonist	99.79%	Unkown
HY-103545	GIP (1-39)	Agonist	/	Unkown
HY-153476	GIP/GLP-1 dual receptor agonist-1	Agonist	/	Unkown
HY-162513	DPP-4-IN-10	Inhibitor	/	Unkown
HY-P0165B	Taspoglutide acetate	Agonist	/	Unkown
HY-P10591	Olatorepatide		/	Unkown
HY-P2080	GIP (1-30) amide,human	Agonist	/	Unkown
HY-P2541	GIP (1-30) amide, porcine	Agonist	/	Unkown
HY-P3577	[Tyr0] Gastric Inhibitory Peptide (23-42), human		/	Unkown
HY-P3578	Gastric Inhibitory Polypeptide (1-30), porcine	Modulator	/	Unkown
HY-P3580	Acetyl Gastric Inhibitory Peptide (human)		/	Unkown
HY-RS05434	GIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gip	NCBI	NCBI:2695
Macaca fascicularis	Gip	NCBI	NCBI:102139187
Mus musculus	Gip	NCBI	NCBI:14607

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