GIP - gastric inhibitory polypeptide Gene

Homo sapiens

Gene ID: 2695 | Gene type: protein coding

About GIP

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,958,554-48,968,596 (from NCBI)

This gene has 1 transcript (splice variant) and 128 orthologues. Biased expression in duodenum (RPKM 96.0) and small intestine (RPKM 33.9).

Summary

This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of Insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates Insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and Other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

GIP Products(1)

mRNA	Protein	Name
NM_004123.3	NP_004114.1	gastric inhibitory polypeptide preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables gastric inhibitory polypeptide receptor binding	IPI IPI: Inferred from physical interaction	17715056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17715056	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	26572091	GOA
involved in gastric inhibitory peptide signaling pathway	IDA IDA: Inferred from direct assay	26572091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIP Protein Structure

Hormone_2

0
100
153 a.a.

Protein Preferred Names

Protein Names

gastric inhibitory polypeptide

glucose-dependent insulinotropic polypeptide

GIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GIP	P09681	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	GIP	P09681	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	GIP	P09681	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	GIP	P09681	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	GIP	P09681	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	GIP	P09681	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	GIP	P09681	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	GIP	P09681	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	GIP	P09681	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GIP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74125	GIP Protein, Human (HEK293, hFc, solution)	NP_004114.1 (E22-Q93)	≥95%
HY-P74125A	GIP Protein, Human (HEK293, hFc)	NP_004114.1 (E22-Q93)	≥95%

Related Diseases

Diseases

Alias

Dumping Syndrome

Jejunal Syndrome	Dumping
Dumping Syndrome	Postgastrectomy Syndromes
Postgastric Surgery Syndrome	Postgastrectomy Syndrome
Post Cibal Syndrome	Postgastrectomy Dumping Syndrome

Hyperglycemia

Adenosquamous Bile Duct Carcinoma

Bile Duct Adenosquamous Carcinoma

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Somatostatinoma

Somatostatin Cell Neoplasm	Somatostatin Cell Tumour
Ampullary Somatostatinoma	Carcinoid Somatostatinoma
Malignant Islet Cell Tumor	Somatomedin-Secreting Carcinoid
Somatostatin-Secreting Pancreatic Neoplasm	Pancreatic Somatostatinoma
Pancreatic Endocrine Carcinoma

Postgastrectomy Syndrome

Postgastrectomy Syndromes

Postgastric Surgery Syndrome

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

Squamous Cell Bile Duct Carcinoma

Bile Duct Squamous Cell Carcinoma

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Functional Gastric Disease

Diabetes Mellitus

Diabetes

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Esophageal Adenosquamous Carcinoma

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0276	GIP, human	Agonist	99.72%	Unkown
HY-P2542	GIP (3-42), human	Antagonist	99.98%	Unkown
HY-P0276A	GIP, human TFA	Agonist	99.88%	Unkown
HY-P2080B	GIP (1-30) amide,human acetate	Agonist	98.24%	Unkown
HY-P10138A	human GIP(3-30), amide TFA	Antagonist	98.82%	Unkown
HY-P3247	[D-Ala2]-GIP (human)	Agonist	98.17%	Unkown
HY-P3579	Gastric Inhibitory Peptide, porcine		99.67%	Unkown
HY-P10138	human GIP(3-30), amide	Antagonist	98.82%	Unkown
HY-P3584A	(Pro3) GIP, human TFA		99.79%	Unkown
HY-P2541A	GIP (1-30) amide, porcine TFA	Agonist	99.95%	Unkown
HY-P3580A	Acetyl Gastric Inhibitory Peptide (human) (TFA)		99.70%	Unkown
HY-P10302A	GLP-1R/GIPR agonist-1 (soduim)	Agonist	96.55%	Unkown
HY-P10302	GLP-1R/GIPR agonist-1	Agonist	/	Unkown
HY-P1434	[Pro3]-GIP (mouse)	Antagonist	/	Unkown
HY-P2080C	GIP (1-30)-Myr	Agonist	/	Unkown
HY-P3255	DA-JC4	Agonist	/	Unkown
HY-P3584	(Pro3) GIP, human	Agonist	99.79%	Unkown
HY-153476	GIP/GLP-1 dual receptor agonist-1	Agonist	/	Unkown
HY-162513	DPP-4-IN-10	Inhibitor	/	Unkown
HY-E70397	Dipeptidyl peptidase IV		/	Unkown
HY-P10591	Olatorepatide		/	Unkown
HY-P10735	GIP (mouse)	Activator	/	Unkown
HY-P2080	GIP (1-30) amide,human	Agonist	/	Unkown
HY-P2541	GIP (1-30) amide, porcine	Agonist	/	Unkown
HY-P3577	[Tyr0] Gastric Inhibitory Peptide (23-42), human		/	Unkown
HY-P3578	Gastric Inhibitory Polypeptide (1-30), porcine	Modulator	/	Unkown
HY-P3580	Acetyl Gastric Inhibitory Peptide (human)		/	Unkown
HY-RS05434	GIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164535	Maridebart cafraglutide	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GIP	VGNC	VGNC:41224
Rattus norvegicus	GIP	RGD	RGD:2709
Macaca mulatta	GIP	VGNC	VGNC:104605
Bos taurus	GIP	VGNC	VGNC:29364
Mus musculus	GIP	MGD	MGI:107504
Felis catus	GIP	VGNC	VGNC:99064
Macaca fascicularis	GIP	NCBI	NCBI:102139187
Others	GIP	NCBI

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