2. Gene
  3. Gip - gastric inhibitory polypeptide Gene

Gip - gastric inhibitory polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14607 | Gene type: protein coding

About Gip

Summary

This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature Peptides that function as potent stimulators of Insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]

Gip Products(2)

mRNA Protein Name
NM_008119.2 NP_032145.2 gastric inhibitory polypeptide preproprotein
NM_008119.2 NP_032145.2 gastric inhibitory polypeptide preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables receptor ligand activity IDA
IDA: Inferred from direct assay
17971513 MGI
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9075801 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
33196462 MGI
acts upstream of or within adult locomotory behavior IDA
IDA: Inferred from direct assay
16822587 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
21270265 MGI
acts upstream of or within exploration behavior IDA
IDA: Inferred from direct assay
16822587 MGI
acts upstream of or within memory IDA
IDA: Inferred from direct assay
16822587 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
9075801 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
33196462 MGI
acts upstream of or within sensory perception of pain IDA
IDA: Inferred from direct assay
16822587 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gastric inhibitory polypeptide

glucose-dependent insulinotropic polypeptide

Recombinant Gip Proteins

Cat. No. Product Name Accession Purity
HY-P77948 GIP Protein, Mouse (HEK293, His) P48756 (E22-Q85) ≥95%
HY-P77949 GIP Protein, Mouse (HEK293, Fc) P48756 (E22-Q85) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-E70397 Dipeptidyl peptidase IV Inhibitor / Phase 4
HY-P10031A SAR441255 TFA Agonist 99.65% Phase 1
HY-P10031 SAR441255 Agonist 99.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0276 GIP, human Agonist 99.72% Unkown
HY-P2542 GIP (3-42), human Antagonist 99.98% Unkown
HY-P10138 human GIP(3-30), amide Antagonist 98.82% Unkown
HY-P10138A human GIP(3-30), amide TFA Antagonist 98.82% Unkown
HY-P0276A GIP, human TFA Agonist 99.88% Unkown
HY-P2080B GIP (1-30) amide,human acetate Agonist 98.24% Unkown
HY-P3247 [D-Ala2]-GIP (human) Agonist 98.56% Unkown
HY-P3579 Gastric Inhibitory Peptide, porcine 99.67% Unkown
HY-P3584A (Pro3) GIP, human TFA 99.79% Unkown
HY-P10735 GIP (mouse) Activator 99.76% Unkown
HY-P2541A GIP (1-30) amide, porcine TFA Agonist 99.95% Unkown
HY-164535 Maridebart cafraglutide Agonist / Unkown
HY-P3580A Acetyl Gastric Inhibitory Peptide (human) (TFA) 99.70% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 96.55% Unkown
HY-P1434 [Pro3]-GIP (mouse) Antagonist 98.87% Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-P2080C GIP (1-30)-Myr Agonist / Unkown
HY-P3255 DA-JC4 Agonist / Unkown
HY-P3584 (Pro3) GIP, human Agonist 99.79% Unkown
HY-103545 GIP (1-39) Agonist / Unkown
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / Unkown
HY-162513 DPP-4-IN-10 Inhibitor / Unkown
HY-P0165B Taspoglutide acetate Agonist / Unkown
HY-P10591 Olatorepatide / Unkown
HY-P2080 GIP (1-30) amide,human Agonist / Unkown
HY-P2541 GIP (1-30) amide, porcine Agonist / Unkown
HY-P3577 [Tyr0] Gastric Inhibitory Peptide (23-42), human / Unkown
HY-P3578 Gastric Inhibitory Polypeptide (1-30), porcine Modulator / Unkown
HY-P3580 Acetyl Gastric Inhibitory Peptide (human) / Unkown
HY-RS05434 GIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gip NCBI NCBI:2695
Macaca fascicularis Gip NCBI NCBI:102139187
Rattus norvegicus Gip NCBI NCBI:25040