2. Gene
  3. F3 - coagulation factor III, tissue factor Gene

F3 - coagulation factor III, tissue factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as TF

Gene ID: 25584 | Gene type: protein coding

About F3

Summary

Enables protease binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface; cytoplasm; and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Apr 2022]

F3 Products(1)

mRNA Protein Name
NM_013057.2 NP_037189.2 tissue factor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protease binding IPI
IPI: Inferred from physical interaction
18315926 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
10190887 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
10190887 RGD
involved in positive regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
10840019 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15481788 RGD
involved in response to fluid shear stress IEP
IEP: Inferred from expression pattern
9974408 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16113797 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15293323 RGD
involved in response to temperature stimulus IEP
IEP: Inferred from expression pattern
16902157 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16902157 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12083485 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tissue factor

coagulation factor 3

coagulation factor III (thromboplastin, tissue factor)

Recombinant F3 Proteins

Cat. No. Product Name Accession Purity
HY-P73592 Tissue Factor Protein, Rat (HEK293, His) Q66HI4 (M1-E252) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104010 Asciminib Inhibitor 99.88% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.84% Yes
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B2203 Monocalcium glycerophosphate Inhibitor ≥98.0% Phase 2
HY-159642 TYRA-300 Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99271 Tisotumab ≥95.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (91)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18960 CHZ868 Inhibitor 99.56% Unkown
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Inhibitor 99.85% Unkown
HY-13491 GNF-5837 Inhibitor 99.65% Unkown
HY-11007 GNF-2 Inhibitor 98.69% Unkown
HY-125834 GMB-475 98.98% Unkown
HY-113437A 1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium ≥98.0% Unkown
HY-N0600 Ginsenoside F3 Modulator 99.84% Unkown
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-18952A (Z)-SU5614 98.09% Unkown
HY-12291 HG6-64-1 Inhibitor 99.69% Unkown
HY-131906 JAK2-IN-7 99.15% Unkown
HY-110026 GTP-14564 Inhibitor 99.91% Unkown
HY-RS03482 CYP4F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-113437AS 1,2-Dipalmitoyl-sn-glycerol 3-phosphate-d62 sodium ≥99.0% Unkown
HY-W081348 1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one 99.54% Unkown
HY-107662 TCS PrP Inhibitor 13 Inducer 99.72% Unkown
HY-113437 1,2-Dipalmitoyl-sn-glycerol 3-phosphate / Unkown
HY-E70134 Endo-β-N-acetylglucosaminidase F3 / Unkown
HY-N8448 3,4-Di-O-caffeoyl quinic acid methyl ester Inhibitor / Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-159147 SIA​​IS039 / Unkown
HY-136526 BCR-ABL-IN-3 Inhibitor / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-112378 D-65476 Inhibitor / Unkown
HY-113777 22-HDHA / Unkown
HY-116597 L-783483 Agonist / Unkown
HY-12083 PPY-A Inhibitor / Unkown
HY-121888 20-HEPE Agonist / Unkown
HY-126619 Aspochalasin D / Unkown
HY-126920 AFG206 / Unkown
HY-129764 Prostaglandin F3α Substrate / Unkown
HY-129764A (17E)-Prostaglandin F3α Control / Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-142922 BCR-ABL-IN-4 Inhibitor / Unkown
HY-144451 TRK-IN-12 Inhibitor / Unkown
HY-146807 Type II TRK inhibitor 1 Inhibitor / Unkown
HY-147813 HIF-1α-IN-3 Inhibitor / Unkown
HY-149965 TRK-IN-23 / Unkown
HY-151048 JBJ-07-149 Inhibitor / Unkown
HY-154465 3’-F-3’-dG(iBu)-2’-phosphoramidite / Unkown
HY-155302 FLT3-IN-22 Inhibitor / Unkown
HY-156086 TRK-IN-24 Inhibitor / Unkown
HY-156102 c-ABL-IN-5 / Unkown
HY-157432 EGFR-IN-97 / Unkown
HY-158465 GPEP FA2-KVANKT glycopeptide / Unkown
HY-161269 EGFR-IN-101 Inhibitor / Unkown
HY-162645 BPR5K230 Inhibitor / Unkown
HY-162881 DS06652923 Inhibitor / Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-163004 Type II TRK inhibitor 2 Inhibitor / Unkown
HY-163366 TRK-IN-28 Inhibitor / Unkown
HY-164397 XMU-MP-5 / Unkown
HY-16983 GNE-3500 Antagonist / Unkown
HY-170497 EGFR-IN-140 Inhibitor / Unkown
HY-E70498 Human CYP4F3,Low-Reductase / Unkown
HY-E70499 Human CYP4F3,High-Reductase / Unkown
HY-E70500 Human CYP4F3,Low-Reductase+b5 / Unkown
HY-E70501 Human CYP4F3,High-Reductase+b5 / Unkown
HY-R01574 hsa-miR-518f-3p mimic / Unkown
HY-R01574A hsa-miR-518f-3p agomir / Unkown
HY-R01603 hsa-miR-520f-3p mimic / Unkown
HY-R01603A hsa-miR-520f-3p agomir / Unkown
HY-R01683 hsa-miR-548f-3p mimic / Unkown
HY-R01683A hsa-miR-548f-3p agomir / Unkown
HY-R03051 mmu-miR-344f-3p mimic / Unkown
HY-R03051A mmu-miR-344f-3p agomir / Unkown
HY-R03176 mmu-miR-466f-3p mimic / Unkown
HY-R03176A mmu-miR-466f-3p agomir / Unkown
HY-R03467 mmu-miR-669f-3p mimic / Unkown
HY-R03467A mmu-miR-669f-3p agomir / Unkown
HY-RI01574 hsa-miR-518f-3p inhibitor / Unkown
HY-RI01574A hsa-miR-518f-3p antagomir / Unkown
HY-RI01603 hsa-miR-520f-3p inhibitor / Unkown
HY-RI01603A hsa-miR-520f-3p antagomir / Unkown
HY-RI01683 hsa-miR-548f-3p inhibitor / Unkown
HY-RI01683A hsa-miR-548f-3p antagomir / Unkown
HY-RI03051 mmu-miR-344f-3p inhibitor / Unkown
HY-RI03051A mmu-miR-344f-3p antagomir / Unkown
HY-RI03176 mmu-miR-466f-3p inhibitor / Unkown
HY-RI03176A mmu-miR-466f-3p antagomir / Unkown
HY-RI03467 mmu-miR-669f-3p inhibitor / Unkown
HY-RI03467A mmu-miR-669f-3p antagomir / Unkown
HY-RS04112 E2F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04643 F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10899 POU2F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10902 POU3F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10906 POU4F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13207 SLC35F3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-116008 8-iso Prostaglandin F3α / Unkown
HY-154031 3'-F-3'-dA(Bz)-2'-Phosphoramidite / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990222 Anti-Mouse IL-17A Antibody (17F3) Inhibitor 99.04% Unkown
HY-P990212 Anti-Mouse IL-6 Antibody (MP5-20F3) Inhibitor 99.20% Unkown
HY-P990411 Anti-F3/Factor III/Tissue Factor/CD142 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F3 NCBI NCBI:2152
Canis familiaris F3 NCBI NCBI:490153
Macaca fascicularis F3 NCBI NCBI:102131431
Mus musculus F3 NCBI NCBI:14066
Leporidae F3 NCBI
Macaca mulatta F3 NCBI NCBI:714456