FBXO7 - F-box protein 7 Gene

Homo sapiens

Also known as FBX; FBX7; PKPS; FBX07; PARK15

Gene ID: 25793 | Gene type: protein coding

About FBXO7

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,474,811-32,498,829 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 94.0), thyroid (RPKM 68.7) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

FBXO7 Products(3)

mRNA	Protein	Name
NM_001033024.2	NP_001028196.1	F-box only protein 7 isoform 2
NM_001257990.2	NP_001244919.1	F-box only protein 7 isoform 3
NM_012179.4	NP_036311.3	F-box only protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15145941	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	18495667	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18495667	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	25029497	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16510124	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	15145941	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	23933751	GOA
acts upstream of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	26310625	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	25029497	GOA
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	26310625	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	36646384	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36646384	GOA
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	23933751	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16510124	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	23933751	GOA
involved in regulation of locomotion	IDA IDA: Inferred from direct assay	26310625	GOA
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	25029497	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	15145941	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25029497	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Lewy body core	IDA IDA: Inferred from direct assay	23656991	GOA
located in Lewy body corona	IDA IDA: Inferred from direct assay	23656991	GOA
located in Lewy neurite	IDA IDA: Inferred from direct assay	23656991	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15145941	GOA
located in classical Lewy body	IDA IDA: Inferred from direct assay	23656991	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16510124	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18495667	GOA
located in glial cytoplasmic inclusion	IDA IDA: Inferred from direct assay	23656991	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23933751	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	36646384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16510124	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	23933751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO7 Protein Structure

PI31_Prot_N

F-box-like

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

F-box only protein 7

Related Diseases

Diseases

Alias

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Parkinson Disease 3, Autosomal Dominant

PARK3	Parkinson Disease 3
Parkinson Disease 3, Autosomal Dominant Lewy Body	Parkinson'S Disease 3
Autosomal Dominant Lewy Body Parkinson Disease 3	Autosomal Dominant Parkinson Disease 3
Parkinson Disease Type 3	Autosomal Dominant Parkinson Disease
Parkinson Disease, Autosomal Dominant	Parkinson Disease, Familial, Type 1

Pyromania

Firesetting Behavior	Pathological Firesetting
Pathological Fire-Setting

Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency	Vertebrobasilar Arterial Insufficiency
Vertebrobasilar Artery Syndrome

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Neurodegeneration With Brain Iron Accumulation 2b

NBIA2B	Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related
Neuroaxonal Dystrophy, Atypical	Karak Syndrome
Atypical Neuroaxonal Dystrophy	Neurodegeneration With Brain Iron Accumulation Pla2g6-Related
Neurodegeneration, With Brain Iron Accumulation, Type 2b	Neurodegeneration With Brain Iron Accumulation 2

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Vascular Parkinsonism

Neuroaxonal Dystrophy

Neuroaxonal Dystrophies

Movement Disease

Movement Disorders

Movement Disorder

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04813	FBXO7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FBXO7	VGNC	VGNC:40789
Macaca mulatta	FBXO7	VGNC	VGNC:72491
Bos taurus	FBXO7	VGNC	VGNC:28919
Felis catus	FBXO7	VGNC	VGNC:62198
Rattus norvegicus	FBXO7	RGD	RGD:1305648
Mus musculus	FBXO7	MGD	MGI:1917004

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