2. Gene
  3. FBXL2 - F-box and leucine rich repeat protein 2 Gene

FBXL2 - F-box and leucine rich repeat protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FBL2; FBL3

Gene ID: 25827 | Gene type: protein coding

About FBXL2

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,277,025-33,422,698 (from NCBI)

This gene has 21 transcripts (splice variants), 218 orthologues and 15 paralogues. Broad expression in brain (RPKM 5.0), testis (RPKM 4.2) and 22 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

FBXL2 Products(10)

mRNA Protein Name
NM_001349316.2 NP_001336245.1 F-box/LRR-repeat protein 2 isoform 3
NM_001349319.2 NP_001336248.1 F-box/LRR-repeat protein 2 isoform 4
NM_001349320.2 NP_001336249.1 F-box/LRR-repeat protein 2 isoform 4
NM_001349321.2 NP_001336250.1 F-box/LRR-repeat protein 2 isoform 4
NM_001349322.2 NP_001336251.1 F-box/LRR-repeat protein 2 isoform 5 precursor
NM_001349323.2 NP_001336252.1 F-box/LRR-repeat protein 2 isoform 6
NM_001349324.2 NP_001336253.1 F-box/LRR-repeat protein 2 isoform 6
NM_001349325.2 NP_001336254.1 F-box/LRR-repeat protein 2 isoform 6
NM_001349326.2 NP_001336255.1 F-box/LRR-repeat protein 2 isoform 6
NM_012157.5 NP_036289.3 F-box/LRR-repeat protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol 3-kinase regulatory subunit binding IPI
IPI: Inferred from physical interaction
23604317 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15893726 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
23604317 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
26037928 GOA
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23604317 GOA
involved in modulation by host of viral RNA genome replication IMP
IMP: Inferred from mutant phenotype
15893726 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
26037928 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23604317 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23604317 GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
23604317 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
23604317 GOA
located in membrane IDA
IDA: Inferred from direct assay
15893726 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL2 Protein Structure

F-box-like

F-box-like: F-box-like (14 - 57)

LRR_6

LRR_6: Leucine Rich repeat (103 - 126)

LRR_6

LRR_6: Leucine Rich repeat (155 - 177)

LRR_6

LRR_6: Leucine Rich repeat (207 - 230)

LRR_6

LRR_6: Leucine Rich repeat (311 - 335)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 2

F-box protein FBL2/FBL3

FBXL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXL2 Q9UKC9 SKP1 Homo sapiens P63208
MAPPIT
19159283
Intra
FBXL2 Q9UKC9 SKP1 Homo sapiens P63208
Y2H Prey Pooling
32296183
Intra
FBXL2 Q9UKC9 SKP1 Homo sapiens P63208
Anti Bait CoIP
26790640
Intra
FBXL2 Q9UKC9 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
25036637
Intra
FBXL2 Q9UKC9 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
FBXL2 Q9UKC9 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
FBXL2 Q9UKC9 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
FBXL2 Q9UKC9 CCT5 Homo sapiens P48643
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129087 BC-​1258 Activator 99.26% Unkown
HY-RS04789 FBXL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FBXL2 VGNC VGNC:97432
Rattus norvegicus FBXL2 RGD RGD:1562243
Mus musculus FBXL2 MGD MGI:1919429
Canis familiaris FBXL2 VGNC VGNC:52879
Bos taurus FBXL2 VGNC VGNC:52775