MPC2 - mitochondrial pyruvate carrier 2 Gene

Homo sapiens

Also known as BRP44; SLC54A2

Gene ID: 25874 | Gene type: protein coding

About MPC2

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,916,675-167,937,072 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in kidney (RPKM 34.8), liver (RPKM 32.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MPC2 Products(2)

mRNA	Protein	Name
NM_001143674.4	NP_001137146.1	mitochondrial pyruvate carrier 2
NM_015415.3	NP_056230.1	mitochondrial pyruvate carrier 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31145700	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial pyruvate transmembrane transport	IDA IDA: Inferred from direct assay	26253029	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	26253029	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPC2 Protein Structure

MPC

0
100
127 a.a.

Protein Preferred Names

Protein Names

mitochondrial pyruvate carrier 2

brain protein 44

MPC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MPC2	O95563	SYT16	Homo sapiens	Q17RD7	Validated Y2H	32296183
Intra	MPC2	O95563	TEX44	Homo sapiens	Q53QW1	Validated Y2H	32296183
Intra	MPC2	O95563	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	MPC2	O95563	APOC1	Homo sapiens	P02654	Validated Y2H	32296183
Intra	MPC2	O95563	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	MPC2	O95563	MICOS10	Homo sapiens	Q5TGZ0	Validated Y2H	32296183
Intra	MPC2	O95563	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	MPC2	O95563	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	MPC2	O95563	RHBDD2	Homo sapiens	Q6NTF9-3	Validated Y2H	32296183
Intra	MPC2	O95563	SNX1	Homo sapiens	Q13596	Validated Y2H	32296183
Intra	MPC2	O95563	MPC1L	Homo sapiens	P0DKB6	TSA	35278701
Intra	MPC2	O95563	MPC1L	Homo sapiens	P0DKB6	Light Scattering	35278701
Intra	MPC2	O95563	MPC1L	Homo sapiens	P0DKB6	Pull Down	35278701
Intra	MPC2	O95563	MPC1L	Homo sapiens	P0DKB6	GMS	35278701
Intra	MPC2	O95563	DIABLO	Homo sapiens	Q9NR28	Validated Y2H	32296183
Intra	MPC2	O95563	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	MPC2	O95563	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	MPC2	O95563	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	MPC2	O95563	MPC1	Homo sapiens	Q9Y5U8	Pull Down	35278701
Intra	MPC2	O95563	MPC1	Homo sapiens	Q9Y5U8	Validated Y2H	32296183
Intra	MPC2	O95563	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mitochondrial Pyruvate Carrier Deficiency

MPYCD

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08607	MPC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MPC2	VGNC	VGNC:107897
Mus musculus	MPC2	MGD	MGI:1917706
Bos taurus	MPC2	VGNC	VGNC:31570
Macaca mulatta	MPC2	VGNC	VGNC:97793
Canis familiaris	MPC2	VGNC	VGNC:43330
Rattus norvegicus	MPC2	RGD	RGD:1563422

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