NSL1 - NSL1 component of MIS12 kinetochore complex Gene

Homo sapiens

Also known as DC8; MIS14; C1orf48

Gene ID: 25936 | Gene type: protein coding

About NSL1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,726,153-212,791,777 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 2.0), lymph node (RPKM 1.8) and 25 other tissues.

Summary

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]

NSL1 Products(5)

mRNA	Protein	Name
NM_001042549.2	NP_001036014.1	kinetochore-associated protein NSL1 homolog isoform 2
NM_001297736.2	NP_001284665.1	kinetochore-associated protein NSL1 homolog isoform 3
NM_001297737.2	NP_001284666.1	kinetochore-associated protein NSL1 homolog isoform 4
NM_001297739.2	NP_001284668.1	kinetochore-associated protein NSL1 homolog isoform 5
NM_015471.4	NP_056286.3	kinetochore-associated protein NSL1 homolog isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15502821	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MIS12/MIND type complex	IDA IDA: Inferred from direct assay	16585270	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	15371340	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	24530301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSL1 Protein Structure

Mis14

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

kinetochore-associated protein NSL1 homolog

NSL1, MIND kinetochore complex component, homolog

Related Diseases

Diseases

Alias

Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09595	NSL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NSL1	VGNC	VGNC:32277
Felis catus	NSL1	VGNC	VGNC:63889
Canis familiaris	NSL1	VGNC	VGNC:43986
Rattus norvegicus	NSL1	RGD	RGD:1562052
Macaca mulatta	NSL1	VGNC	VGNC:75454
Mus musculus	NSL1	MGD	MGI:2685830

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