DSN1 - DSN1 component of MIS12 kinetochore complex Gene

Homo sapiens

Also known as KNL3; MIS13; hKNL-3; C20orf172; dJ469A13.2

Gene ID: 79980 | Gene type: protein coding

About DSN1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,751,795-36,773,763 (from NCBI)

This gene has 10 transcripts (splice variants) and 174 orthologues. Broad expression in testis (RPKM 11.7), lymph node (RPKM 6.7) and 24 other tissues.

Summary

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

DSN1 Products(5)

mRNA	Protein	Name
NM_001145315.2	NP_001138787.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145316.2	NP_001138788.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145317.2	NP_001138789.1	kinetochore-associated protein DSN1 homolog isoform 2
NM_001145318.2	NP_001138790.1	kinetochore-associated protein DSN1 homolog isoform 3
NM_024918.4	NP_079194.3	kinetochore-associated protein DSN1 homolog isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15371340	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MIS12/MIND type complex	IDA IDA: Inferred from direct assay	16585270	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	15371340	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	24530301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSN1 Protein Structure

MIS13

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

kinetochore-associated protein DSN1 homolog

DSN1 homolog, MIS12 kinetochore complex component

DSN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	GMS	23334297
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	24981860
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	26496610
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	27705803
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BRET	37398436
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BiLC	37398436
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	33961781
Intra	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	28514442
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Validated Y2H	32814053
Intra	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Array	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Lumier	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BRET	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	GMS	23334297
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	24981860
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	27705803
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BiLC	37398436
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	33961781
Intra	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	26496610
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Array	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Pooling	32814053
Intra	DSN1	Q9H410	BGN	Homo sapiens	P21810	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma

Arts Syndrome

ARTS	Mrxsarts
Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision	Mrxs18
Lethal Ataxia With Deafness And Optic Atrophy	Fatal X-Linked Ataxia With Deafness And Loss Of Vision
Mental Retardation, X-Linked, Syndromic, Arts Type	Mental Retardation, X-Linked, Syndromic 18
Syndromic X-Linked Mental Retardation 18	Syndromic X-Linked Mental Retardation Arts Type
Lethal Ataxia-Deafness-Optic Atrophy	X-Linked Fatal Ataxia With Deafness And Loss Of Vision
Ataxia-Deafness-Optic Atrophy, Lethal	Lethal Ataxia With Hearing Loss And Optic Atrophy
Art

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04025	DSN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DSN1	VGNC	VGNC:71846
Canis familiaris	DSN1	VGNC	VGNC:40109
Bos taurus	DSN1	VGNC	VGNC:28224
Mus musculus	DSN1	MGD	MGI:1914184
Felis catus	DSN1	VGNC	VGNC:61639
Rattus norvegicus	DSN1	RGD	RGD:1565179

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