FBXO3 - F-box protein 3 Gene

Homo sapiens

Also known as FBA; FBX3

Gene ID: 26273 | Gene type: protein coding

About FBXO3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,740,944-33,774,520 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

FBXO3 Products(2)

mRNA	Protein	Name
NM_012175.4	NP_036307.2	F-box only protein 3 isoform 1
NM_033406.4	NP_208385.1	F-box only protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21145461	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	26037928	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	26037928	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	26037928	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	26037928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO3 Protein Structure

F-box-like

SMI1_KNR4

DUF525

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

F-box only protein 3

F-box protein FBX3

FBXO3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXO3	Q9UK99	SKP1	Homo sapiens	P63208	Y2H	21516116
Intra	FBXO3	Q9UK99	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO3	Q9UK99	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	32296183
Intra	FBXO3	Q9UK99	SKP1	Homo sapiens	P63208	Anti Tag CoIP	33961781
Intra	FBXO3	Q9UK99	SKP1	Homo sapiens	P63208	Y2H Array	32296183
Intra	FBXO3	Q9UK99	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	FBXO3	Q9UK99	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	21145461
Cross	FBXO3	Q9UK99	tat	Human immunodeficiency virus	P04608	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rift Valley Fever

Rfv - [Rift Valley Fever]

3-Methylglutaconic Aciduria, Type I

3-Methylglutaconyl-Coa Hydratase Deficiency	3-Methylglutaconic Aciduria Type 1
Mga1	MGCA1
3mg-Coa Hydratase Deficiency	Mga Type I
Mga, Type I	3-Mg-Coa-Hydratase Deficiency
3 Methylglutaconyl Coa Hydratase Deficiency	3-Methylglutaconic Aciduria Type I
3 Alpha Methylglutaconic Aciduria Type I	3 Methylglutaconic Aciduria Type 1
3-Mgca Type I	3mg Coa Hydratase Deficiency
Auh Defect	Primary 3-Methylglutaconic Aciduria
3-Methylglutaconic Aciduria 1	3-Alpha-Methylglutaconic Aciduria Type 1
3-Alpha-Methylglutaconyl-Coa Hydratase Deficiency	3-@Methylglutaconic Aciduria, Type I
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Congenital Bile Acid Synthesis Defect

3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency	Cba
Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency	Basd
Bile Acid Synthesis Defect, Congenital, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117937	BC-1215	Inhibitor	99.93%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FBXO3	RGD	RGD:1593433
Felis catus	FBXO3	VGNC	VGNC:62184
Bos taurus	FBXO3	VGNC	VGNC:28902
Mus musculus	FBXO3	MGD	MGI:1929084
Macaca mulatta	FBXO3	VGNC	VGNC:72487
Canis familiaris	FBXO3	VGNC	VGNC:40771

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