Fto - fat mass and obesity associated Gene

Mus musculus

Also known as mKIAA1752

Gene ID: 26383 | Gene type: protein coding

About Fto

Chromosome 8: 92,040,153-92,395,067 forward strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 202 orthologues and is associated with 54 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 3.4) and 28 other tissues.

Summary

Enables DNA-N1-methyladenine dioxygenase activity; oxidative DNA demethylase activity; and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and salivary gland. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto Products(1)

mRNA	Protein	Name
NM_011936.2	NP_036066.2	alpha-ketoglutarate-dependent dioxygenase FTO

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-oxoglutarate-dependent dioxygenase activity	IDA IDA: Inferred from direct assay	17991826	MGI
enables broad specificity oxidative DNA demethylase activity	IDA IDA: Inferred from direct assay	18775698	MGI
enables oxidative RNA demethylase activity	IDA IDA: Inferred from direct assay	18775698	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	18775698	MGI
involved in RNA repair	IDA IDA: Inferred from direct assay	18775698	MGI
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	19234441	MGI
involved in regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	19234441	MGI
involved in regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	19234441	MGI
involved in regulation of respiratory system process	IMP IMP: Inferred from mutant phenotype	19234441	MGI
involved in regulation of white fat cell proliferation	IMP IMP: Inferred from mutant phenotype	19234441	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	19234441	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17991826	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fto Protein Structure

FTO_NTD

FTO_CTD

0
100
200
300
400
502 a.a.

Protein Preferred Names

Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO	U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
fat mass and obesity-associated protein	m6A(m)-demethylase FTO
mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO	mRNA N(6)-methyladenosine demethylase FTO
protein fatso	tRNA N1-methyl adenine demethylase FTO

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-B1320	Meclofenamic acid sodium	Inhibitor	99.86%	Unkown
HY-117275	Meclofenamic acid	Inhibitor	98.60%	Unkown
HY-101082	N6,2′-O-Dimethyladenosine	Inhibitor	99.93%	Unkown
HY-117275A	Meclofenamic acid sodium hydrate	Inhibitor	/	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-127103	FB23-2	Inducer	99.93%	Unkown
HY-137187	FB23		98.66%	Unkown
HY-N6769	Radicicol	Inhibitor	99.63%	Unkown
HY-151106	FTO-IN-8	Inhibitor	98.03%	Unkown
HY-145238	FTO-IN-6		98.94%	Unkown
HY-138843A	FTO-IN-1 TFA		98.06%	Unkown
HY-149334	ZLD115	Inhibitor	99.24%	Unkown
HY-147011	FTO-IN-7	Inhibitor	99.22%	Unkown
HY-132865	FTO-IN-3		99.79%	Unkown
HY-RS05137	Fto Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W588293	3-Methylthymidine		99.68%	Unkown
HY-117275S1	Meclofenamic acid-13C6	Inhibitor	/	Unkown
HY-117426	MO-I-500	Inhibitor	99.10%	Unkown
HY-132863	FTO-IN-2		/	Unkown
HY-138843	FTO-IN-1		/	Unkown
HY-139820	FTO-IN-4		/	Unkown
HY-139821	FTO-IN-5		/	Unkown
HY-156405	FTO-IN-10		/	Unkown
HY-N10340	Clausine E	Inhibitor	/	Unkown
HY-RS05136	FTO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05138	Fto Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W026109	FTO-IN-12	Inhibitor	/	Unkown
HY-131871	Ethyl LipotF	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fto	NCBI	NCBI:79068

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