2. Gene
  3. FADD - Fas associated via death domain Gene

FADD - Fas associated via death domain Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GIG3; IMD90; MORT1

Gene ID: 8772 | Gene type: protein coding

About FADD

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:70,203,296-70,207,390 (from NCBI)

This gene has 1 transcript (splice variant), 180 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit Caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

FADD Products(1)

mRNA Protein Name
NM_003824.4 NP_003815.1 FAS-associated death domain protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables caspase binding IDA
IDA: Inferred from direct assay
24025841 GOA
enables caspase binding IPI
IPI: Inferred from physical interaction
9343261 GOA
enables death effector domain binding IPI
IPI: Inferred from physical interaction
11717445 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
7536190 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
9208847 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7536190 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
8565075 GOA
enables tumor necrosis factor receptor superfamily binding IPI
IPI: Inferred from physical interaction
21109225 GOA
Biological Process GO Annotation Evidence Reference Source
involved in TRAIL-activated apoptotic signaling pathway IDA
IDA: Inferred from direct assay
21785459 GOA
involved in activation of cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
18387192 GOA
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
22891283 GOA
involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
8565075 GOA
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19593445 GOA
involved in death-inducing signaling complex assembly IDA
IDA: Inferred from direct assay
24025841 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
21109225 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
21785459 GOA
involved in extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16611992 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
9184224 GOA
involved in necroptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11101870 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
11821383 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20935634 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21525013 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
17047155 GOA
involved in positive regulation of proteolysis IDA
IDA: Inferred from direct assay
18387192 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21109225 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
20935634 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22510408 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21785459 GOA
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
11101870 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22510408 GOA
part of ripoptosome IDA
IDA: Inferred from direct assay
21737330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FADD Protein Structure

DED

DED: Death effector domain (4 - 84)

Death

Death: Death domain (101 - 179)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

FAS-associated death domain protein

Fas (TNFRSF6)-associated via death domain

FADD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FADD Q13158 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra FADD Q13158 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra FADD Q13158 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra FADD Q13158 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra FADD Q13158 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra FADD Q13158 PARK7 Homo sapiens Q99497
Pull Down
21785459
Intra FADD Q13158 PARK7 Homo sapiens Q99497
Anti Bait CoIP
21785459
Intra FADD Q13158 PARK7 Homo sapiens Q99497
Anti Tag CoIP
21785459
Intra FADD Q13158 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Prey Pooling
32296183
Intra FADD Q13158 ZMYM5 Homo sapiens Q9UJ78-2
Validated Y2H
32296183
Intra FADD Q13158 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Array
32296183
Intra FADD Q13158 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra FADD Q13158 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra FADD Q13158 CASP8 Homo sapiens Q14790-1
Anti Tag CoIP
8681376
Intra FADD Q13158 CASP8 Homo sapiens Q14790-1
Y2H
8681376
Intra FADD Q13158 CASP8 Homo sapiens Q14790-5
Anti Tag CoIP
8681376
Intra FADD Q13158 CASP8 Homo sapiens Q14790-5
Y2H
8681376
Cross FADD Q13158 Fas Mus musculus P25446
X-Ray Diffraction
20935634
Cross FADD Q13158 Fas Mus musculus P25446
TEM
20935634
Cross FADD Q13158 Fas Mus musculus P25446
SLCA
20935634
Cross FADD Q13158 Fas Mus musculus P25446
Light Scattering
20935634
Cross FADD Q13158 Fas Mus musculus P25446
Pull Down
7536190
Cross FADD Q13158 Fas Mus musculus P25446
GMS
20935634
Cross FADD Q13158 Fas Mus musculus P25446
Pull Down
20935634
Intra FADD Q13158 MBD4 Homo sapiens O95243
Y2H
12702765
Intra FADD Q13158 MBD4 Homo sapiens O95243
CoIP
12702765
Intra FADD Q13158 MBD4 Homo sapiens O95243
Pull Down
12702765
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
Validated Y2H
32296183
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
Anti Tag CoIP
33961781
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
Anti Bait CoIP
19524513
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
Anti Tag CoIP
19524513
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
Anti Bait CoIP
21458669
Intra FADD Q13158 RIPK1 Homo sapiens Q13546
ViroTrap
30561431
Intra FADD Q13158 TRADD Homo sapiens Q15628
Y2H Array
32296183
Intra FADD Q13158 TRADD Homo sapiens Q15628
Validated Y2H
32296183
Intra FADD Q13158 TRADD Homo sapiens Q15628
Y2H
11112409
Intra FADD Q13158 TRADD Homo sapiens Q15628
Y2H Prey Pooling
32296183
Intra FADD Q13158 MYD88 Homo sapiens Q99836
Y2H
21988832
Intra FADD Q13158 PLK1 Homo sapiens P53350
GMS
20890306
Intra FADD Q13158 PLK1 Homo sapiens P53350
Confocal
20890306
Intra FADD Q13158 PLK1 Homo sapiens P53350
Pull Down
20890306
Intra FADD Q13158 PLK1 Homo sapiens P53350
Protein Kinase Assay
20890306
Intra FADD Q13158 FAS Homo sapiens P25445
Pull Down
7538907
Intra FADD Q13158 FAS Homo sapiens P25445
CoIP
7536190
Intra FADD Q13158 FAS Homo sapiens P25445
Anti Bait CoIP
21382479
Intra FADD Q13158 FAS Homo sapiens P25445
Anti Tag CoIP
16498403
Intra FADD Q13158 FASLG Homo sapiens P48023
PLA
25241761
Intra FADD Q13158 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
19176810
Intra FADD Q13158 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra FADD Q13158 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra FADD Q13158 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra FADD Q13158 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra FADD Q13158 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra FADD Q13158 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra FADD Q13158 BTG1 Homo sapiens P62324
Y2H Prey Pooling
32296183
Intra FADD Q13158 BTG1 Homo sapiens P62324
Y2H Array
32296183
Intra FADD Q13158 ZCCHC12 Homo sapiens Q6PEW1
Y2H Prey Pooling
32296183
Intra FADD Q13158 ZCCHC12 Homo sapiens Q6PEW1
Validated Y2H
32296183
Intra FADD Q13158 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 90 With Encephalopathy, Functional Hyposplenia, And Hepatic Dysfunction

Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations

Fadd-Related Immunodeficiency

IMD90

Fadd Deficiency

Infections, Recurrent, Associated With Encephalopathy, Hepatic Dysfunction And Cardiovascular Malformations

IEHDCM
Otodental Dysplasia

Otodental Syndrome

Oculootodental Syndrome

Chromosome 11q13 Deletion Syndrome

Otodental Dysplasia Chromosome Deletion Syndrome

Globodontia

Ood
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b

Caspase-8 Deficiency

Ceds

Alps2b

Autoimmune Lymphoproliferative Syndrome, Type Iib

Alps With Recurrent Viral Infections

Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

Caspase 8 Deficiency Syndrome

Caspase 8 Lymphadenopathy Syndrome

Autoimmune Lymphoproliferative Syndrome Type Iib

Caspase Eight Deficiency State

CASP8D
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Type 1 Diabetes Mellitus 4

Diabetes Mellitus, Insulin-Dependent, 4

Iddm4

Insulin-Dependent Diabetes Mellitus 4

T1D4

Insulin-Dependent Diabetes Mellitus-4
Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal
Cervical Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of The Cervix Uteri
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14622 Necrostatin 2 Inhibitor 99.92% Unkown
HY-109582 ADT-OH Inducer 99.06% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-148454 Necroptosis-IN-3 Inhibitor 99.77% Unkown
HY-119369 FadD32 Inhibitor-1 Inhibitor / Unkown
HY-RS04665 FADD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FADD MGD MGI:109324
Rattus norvegicus FADD RGD RGD:628700
Felis catus FADD VGNC VGNC:102880
Bos taurus FADD VGNC VGNC:28700
Macaca mulatta FADD VGNC VGNC:110502
Canis familiaris FADD VGNC VGNC:51869
Others FADD NCBI