VPS37B - VPS37B subunit of ESCRT-I Gene

Homo sapiens

Gene ID: 79720 | Gene type: protein coding

About VPS37B

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,865,330-122,896,124 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues.

Summary

Enables calcium-dependent protein binding activity. Involved in positive regulation of viral budding via host ESCRT complex. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]

VPS37B Products(1)

mRNA	Protein	Name
NM_024667.3	NP_078943.1	vacuolar protein sorting-associated protein 37B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	23924735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15218037	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of viral budding via host ESCRT complex	IMP IMP: Inferred from mutant phenotype	15218037	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	15218037	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESCRT I complex	IDA IDA: Inferred from direct assay	18005716	GOA
part of ESCRT I complex	IPI IPI: Inferred from physical interaction	18005716	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15218037	GOA
located in endosome	IDA IDA: Inferred from direct assay	17940959	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15218037	GOA
located in midbody	IDA IDA: Inferred from direct assay	19129479	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17940959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS37B Protein Structure

Mod_r

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 37B

ESCRT-I complex subunit VPS37B

VPS37B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VPS37B	Q9H9H4	QARS1	Homo sapiens	P47897-2	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	QARS1	Homo sapiens	P47897-2	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	VPS28	Homo sapiens	Q548N1	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	PRKAA1	Homo sapiens	Q13131	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	25416956
Intra	VPS37B	Q9H9H4	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	35271311
Intra	VPS37B	Q9H9H4	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	VPS37B	Q9H9H4	SMARCD1	Homo sapiens	Q96GM5	Y2H	21516116
Intra	VPS37B	Q9H9H4	SMARCD1	Homo sapiens	Q96GM5	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	VPS37B	Q9H9H4	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	SH3YL1	Homo sapiens	Q96HL8	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	SH3YL1	Homo sapiens	Q96HL8	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	VPS28	Homo sapiens	Q9UK41	Y2H	21516116
Intra	VPS37B	Q9H9H4	VPS28	Homo sapiens	Q9UK41	Anti Tag CoIP	35271311
Intra	VPS37B	Q9H9H4	DCUN1D1	Homo sapiens	Q96GG9	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	DCUN1D1	Homo sapiens	Q96GG9	Y2H Array	25416956
Intra	VPS37B	Q9H9H4	DCUN1D1	Homo sapiens	Q96GG9	Y2H Prey Pooling	25416956
Intra	VPS37B	Q9H9H4	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Intra	VPS37B	Q9H9H4	ERCC1	Homo sapiens	P07992	Validated Y2H	25416956
Intra	VPS37B	Q9H9H4	CDC73	Homo sapiens	Q6P1J9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15689	VPS37B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VPS37B	VGNC	VGNC:107022
Rattus norvegicus	VPS37B	RGD	RGD:1304576
Macaca mulatta	VPS37B	VGNC	VGNC:100117
Mus musculus	VPS37B	MGD	MGI:1916724
Felis catus	VPS37B	VGNC	VGNC:107733

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