2. Gene
  3. VPS37B - VPS37B subunit of ESCRT-I Gene

VPS37B - VPS37B subunit of ESCRT-I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 79720 | Gene type: protein coding

About VPS37B

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,865,330-122,896,124 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues.

Summary

Enables calcium-dependent protein binding activity. Involved in positive regulation of viral budding via host ESCRT complex. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]

VPS37B Products(1)

mRNA Protein Name
NM_024667.3 NP_078943.1 vacuolar protein sorting-associated protein 37B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
23924735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15218037 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of viral budding via host ESCRT complex IMP
IMP: Inferred from mutant phenotype
15218037 GOA
involved in viral release from host cell IMP
IMP: Inferred from mutant phenotype
15218037 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ESCRT I complex IDA
IDA: Inferred from direct assay
18005716 GOA
part of ESCRT I complex IPI
IPI: Inferred from physical interaction
18005716 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15218037 GOA
located in endosome IDA
IDA: Inferred from direct assay
17940959 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
15218037 GOA
located in midbody IDA
IDA: Inferred from direct assay
19129479 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17940959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS37B Protein Structure

Mod_r

Mod_r: Modifier of rudimentary (Mod(r)) protein (12 - 159)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 37B

ESCRT-I complex subunit VPS37B

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15689 VPS37B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VPS37B VGNC VGNC:107022
Rattus norvegicus VPS37B RGD RGD:1304576
Macaca mulatta VPS37B VGNC VGNC:100117
Mus musculus VPS37B MGD MGI:1916724
Felis catus VPS37B VGNC VGNC:107733