2. Gene
  3. INPP5J - inositol polyphosphate-5-phosphatase J Gene

INPP5J - inositol polyphosphate-5-phosphatase J Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PIPP; INPP5; PIB5PA

Gene ID: 27124 | Gene type: protein coding

About INPP5J

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,122,923-31,134,697 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 13 paralogues. Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues.

Summary

Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

INPP5J Products(6)

mRNA Protein Name
NM_001002837.2 NP_001002837.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c
NM_001284285.2 NP_001271214.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a
NM_001284286.1 NP_001271215.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b
NM_001284287.1 NP_001271216.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d
NM_001284288.1 NP_001271217.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e
NM_001284289.1 NP_001271218.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12536145 GOA
located in ruffle IDA
IDA: Inferred from direct assay
12536145 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5J Protein Structure

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (428 - 721)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1006 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

INPP5J Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra INPP5J Q15735 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra INPP5J Q15735 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra INPP5J Q15735 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra INPP5J Q15735 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra INPP5J Q15735 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra INPP5J Q15735 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra INPP5J Q15735 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra INPP5J Q15735 PSME3 Homo sapiens P61289
Y2H Array
32296183
Intra INPP5J Q15735 PSME3 Homo sapiens P61289
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
25416956
Intra INPP5J Q15735 CDC23 Homo sapiens Q9UJX2
Validated Y2H
25416956
Intra INPP5J Q15735 PELI1 Homo sapiens Q96FA3
Validated Y2H
32296183
Intra INPP5J Q15735 PELI1 Homo sapiens Q96FA3
Y2H Array
32296183
Intra INPP5J Q15735 PELI1 Homo sapiens Q96FA3
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra INPP5J Q15735 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra INPP5J Q15735 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra INPP5J Q15735 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
32296183
Intra INPP5J Q15735 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra INPP5J Q15735 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra INPP5J Q15735 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra INPP5J Q15735 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra INPP5J Q15735 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra INPP5J Q15735 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra INPP5J Q15735 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lowe Oculocerebrorenal Syndrome

Lowe Syndrome

Oculocerebrorenal Syndrome

OCRL

Oculocerebrorenal Syndrome Of Lowe

Ocrl1

Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency

Lowe Disease

Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency

Cerebrooculorenal Syndrome

Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency

Lowe Oculo-Cerebro-Renal Dystrophy

Lowe Oculo-Cerebro-Renal Syndrome

Lowe Oculocerebrorenal Dystrophy

Low

Chromosome 11p Deletion Syndrome

Oculocerebrorenal Dystrophy

Cerebro-Oculorenal Dystrophy

Ocrl1 - [Oculocerebrorenal Syndrome]

Lowe-Terrey-Maclachlan Syndrome

Renal-Oculocerebrodystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06832 INPP5J Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INPP5J VGNC VGNC:53909
Felis catus INPP5J VGNC VGNC:68841
Canis familiaris INPP5J VGNC VGNC:42035
Macaca mulatta INPP5J VGNC VGNC:73814
Rattus norvegicus INPP5J RGD RGD:620541
Mus musculus INPP5J MGD MGI:2158663