Prmt5 - protein arginine N-methyltransferase 5 Gene

Mus musculus

Also known as Jbp1; Skb1

Gene ID: 27374 | Gene type: protein coding

About Prmt5

Chromosome 14: 54,744,644-54,754,982 reverse strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 200 orthologues and is associated with 3 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues.

Summary

This gene encodes an Enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Prmt5 Products(3)

mRNA	Protein	Name
NM_001313907.1	NP_001300836.1	protein arginine N-methyltransferase 5 isoform 3
NM_013768.3	NP_038796.2	protein arginine N-methyltransferase 5 isoform 1
NM_001313906.1	NP_001300835.1	protein arginine N-methyltransferase 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables E-box binding	IDA IDA: Inferred from direct assay	23133559	MGI
enables chromatin binding	IMP IMP: Inferred from mutant phenotype	18347060	MGI
enables histone H2AR3 methyltransferase activity	IDA IDA: Inferred from direct assay	16699504	MGI
enables histone H4R3 methyltransferase activity	IDA IDA: Inferred from direct assay	16699504	MGI
enables histone H4R3 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	23133559	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16699504	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	23133559	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23133559	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	16699504	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18347060	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16699504	MGI
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	23048031	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	16787967	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16699504	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt5 Protein Structure

PRMT5_TIM

PRMT5

PRMT5_C

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 5

Jak-binding protein 1	SKB1 homolog
histone-arginine N-methyltransferase PRMT5	shk1 kinase-binding protein 1 homolog

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101563	GSK3326595	Inhibitor	99.97%	Phase 2
HY-139611	MRTX-1719	Inhibitor	99.40%	Phase 2
HY-148419	TNG908	Inhibitor	98.89%	Phase 2
HY-101564	Onametostat	Inhibitor	99.79%	Phase 1
HY-131493	PF-06939999	Inhibitor	99.69%	Phase 1

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12727	EPZ015666	Inhibitor	99.83%	Unkown
HY-100235	GSK591	Inhibitor	99.91%	Unkown
HY-107777	LLY-283	Inhibitor	99.22%	Unkown
HY-138684	MRTX9768	Inhibitor	99.60%	Unkown
HY-148674	PRMT5-IN-25	Inhibitor	99.94%	Unkown
HY-124131	DS-437	Inhibitor	98.00%	Unkown
HY-100025A	HLCL-61 hydrochloride	Inhibitor	99.87%	Unkown
HY-132309	BRD0639	Inhibitor	98.04%	Unkown
HY-139611C	MRTX-1719 hydrochloride	Inhibitor	99.22%	Unkown
HY-120137	CMP-5	Inhibitor	99.02%	Unkown
HY-128579	DW14800	Inhibitor	99.63%	Unkown
HY-109963	PR5-LL-CM01	Inhibitor	98.45%	Unkown
HY-Q36691	PRMT5-IN-30	Inhibitor	99.17%	Unkown
HY-126256	PRMT5-IN-1	Inhibitor	/	Unkown
HY-134883	PRMT5-IN-4	Inhibitor	≥99.0%	Unkown
HY-141876	PRMT5-IN-14	Inhibitor	/	Unkown
HY-163591	PRMT5-IN-36-d3	Inhibitor	/	Unkown
HY-158143	PRMT5-IN-34	Inhibitor	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-163587	PRMT5-IN-39-d3	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-163593	PRMT5-IN-44	Inhibitor	/	Unkown
HY-163592	PRMT5-IN-43	Inhibitor	/	Unkown
HY-168263	PRMT5-IN-45	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-150081	PRMT5-IN-21	Inhibitor	/	Unkown
HY-163799	PRMT5-MTA-IN-1	Inhibitor	/	Unkown
HY-P3822	PRMT5-IN-23	Inhibitor	/	Unkown
HY-132937	PRMT5-IN-9	Inhibitor	/	Unkown
HY-139611B	(S)-MRTX-1719	Inhibitor	97.07%	Unkown
HY-153421	PRMT5-IN-28	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt5	NCBI	NCBI:10419

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