VTI1B - vesicle transport through interaction with t-SNAREs 1B Gene

Homo sapiens

Also known as VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE

Gene ID: 10490 | Gene type: protein coding

About VTI1B

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,647,085-67,674,632 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 68.1), kidney (RPKM 45.6) and 25 other tissues.

Summary

Enables SNARE binding activity and Chloride Channel Inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VTI1B Products(1)

mRNA	Protein	Name
NM_006370.3	NP_006361.1	vesicle transport through interaction with t-SNAREs homolog 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	24550300	GOA
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	18570918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23217709	GOA
involved in regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18570918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19224922	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	18033301	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	18033301	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18033301	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18570918	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18570918	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	18033301	GOA
located in vesicle	IDA IDA: Inferred from direct assay	18570918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VTI1B Protein Structure

V-SNARE

V-SNARE_C

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

vesicle transport through interaction with t-SNAREs homolog 1B

vesicle transport v-SNARE protein Vti1-like 1

VTI1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VTI1B	Q9UEU0	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	VTI1B	Q9UEU0	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	31515488
Intra	VTI1B	Q9UEU0	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	25416956
Intra	VTI1B	Q9UEU0	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	25416956
Intra	VTI1B	Q9UEU0	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	TRIM59	Homo sapiens	Q8IWR1	Y2H Array	25416956
Intra	VTI1B	Q9UEU0	TRIM59	Homo sapiens	Q8IWR1	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	TRIM59	Homo sapiens	Q8IWR1	Y2H Prey Pooling	25416956
Intra	VTI1B	Q9UEU0	TRIM59	Homo sapiens	Q8IWR1	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	TRIM59	Homo sapiens	Q8IWR1	Y2H Array	31515488
Intra	VTI1B	Q9UEU0	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	PTPN5	Homo sapiens	P54829	Y2H Array	25416956
Intra	VTI1B	Q9UEU0	PTPN5	Homo sapiens	P54829	Y2H Prey Pooling	25416956
Intra	VTI1B	Q9UEU0	PTPN5	Homo sapiens	P54829	Validated Y2H	25416956
Intra	VTI1B	Q9UEU0	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	CD46	Homo sapiens	P15529-3	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	CD46	Homo sapiens	P15529-3	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Anti Tag CoIP	33961781
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Anti Tag CoIP	28514442
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX8	Homo sapiens	Q9UNK0	Anti Tag CoIP	35271311
Intra	VTI1B	Q9UEU0	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	STX4	Homo sapiens	Q12846	Y2H Array	25416956
Intra	VTI1B	Q9UEU0	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	VTI1B	Q9UEU0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	TMEM234	Homo sapiens	Q8WY98	Y2H Prey Pooling	32296183
Intra	VTI1B	Q9UEU0	TMEM234	Homo sapiens	Q8WY98	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	VTI1B	Q9UEU0	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15723	VTI1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VTI1B	MGD	MGI:1855688
Macaca mulatta	VTI1B	VGNC	VGNC:99341
Rattus norvegicus	VTI1B	RGD	RGD:2323682
Felis catus	VTI1B	VGNC	VGNC:80781
Bos taurus	VTI1B	VGNC	VGNC:36849
Canis familiaris	VTI1B	VGNC	VGNC:48317

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