2. Gene
  3. MKNK2 - MAPK interacting serine/threonine kinase 2 Gene

MKNK2 - MAPK interacting serine/threonine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MNK2; GPRK7

Gene ID: 2872 | Gene type: protein coding

About MKNK2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,037,471-2,051,244 (from NCBI)

This gene has 12 transcripts (splice variants), 224 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 52.7), bone marrow (RPKM 47.1) and 25 other tissues.

Summary

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CaMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin Ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

MKNK2 Products(2)

mRNA Protein Name
NM_199054.3 NP_951009.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
NM_017572.4 NP_060042.2 MAP kinase-interacting serine/threonine-protein kinase 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
11463832 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11463832 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to arsenic-containing substance IDA
IDA: Inferred from direct assay
18299328 GOA
involved in hemopoiesis IDA
IDA: Inferred from direct assay
21149447 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11463832 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11463832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MKNK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (88 - 368)

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  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

MAP kinase-interacting serine/threonine-protein kinase 2

G protein-coupled receptor kinase 7

MAP kinase interacting serine/threonine kinase 2

MAP kinase signal-integrating kinase 2

MAPK signal-integrating kinase 2

MKNK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MKNK2 Q9HBH9 MAPK14 Homo sapiens Q16539
Y2H Pooling
20936779
Intra
MKNK2 Q9HBH9 MAPK14 Homo sapiens Q16539
Pull Down
32707033
Intra
MKNK2 Q9HBH9 MAPK14 Homo sapiens Q16539
PLA
25241761
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-RS08476 MKNK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08477 Mknk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08478 Mknk2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MKNK2 VGNC VGNC:68265
Bos taurus MKNK2 VGNC VGNC:31492
Canis familiaris MKNK2 VGNC VGNC:43251
Rattus norvegicus MKNK2 RGD RGD:1305728
Macaca mulatta MKNK2 VGNC VGNC:74877
Mus musculus MKNK2 MGD MGI:894279
Others MKNK2 NCBI