DCPS - decapping enzyme, scavenger Gene

Homo sapiens

Also known as ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015

Gene ID: 28960 | Gene type: protein coding

About DCPS

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,304,060-126,350,005 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues.

Summary

This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This Enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of Other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and MicroRNA turnover. [provided by RefSeq, Apr 2017]

DCPS Products(2)

mRNA	Protein	Name
NM_001350236.2	NP_001337165.1	m7GpppX diphosphatase isoform 1
NM_014026.6	NP_054745.1	m7GpppX diphosphatase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IDA IDA: Inferred from direct assay	12198172	GOA
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	12198172	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16140270	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA cis splicing, via spliceosome	IDA IDA: Inferred from direct assay	18426921	GOA
involved in mRNA methylguanosine-cap decapping	IDA IDA: Inferred from direct assay	26049109	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18441014	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12871939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCPS Protein Structure

DcpS

DcpS_C

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

m7GpppX diphosphatase

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

DCPS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCPS	Q96C86	KPNA2	Homo sapiens	P52292	Y2H Array	32296183
Intra	DCPS	Q96C86	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	32296183
Intra	DCPS	Q96C86	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	DCPS	Q96C86	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	DCPS	Q96C86	DCPS	Homo sapiens	Q96C86	Y2H Prey Pooling	32296183
Intra	DCPS	Q96C86	DCPS	Homo sapiens	Q96C86	Validated Y2H	32296183
Intra	DCPS	Q96C86	CHST4	Homo sapiens	Q8NCG5	Y2H Array	21988832
Intra	DCPS	Q96C86	DCPS	Homo sapiens	Q96C86	Y2H Array	32296183
Intra	DCPS	Q96C86	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	DCPS	Q96C86	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	DCPS	Q96C86	SSRP1	Homo sapiens	Q08945	Crosslink	30021884
Intra	DCPS	Q96C86	GPC5	Homo sapiens	P78333	Y2H Array	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Al-Raqad Syndrome

ARS

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease	SMA1
Spinal Muscular Atrophy 1	Sma I
Sma, Infantile Acute Form	Muscular Atrophy, Infantile
Spinal Muscular Atrophy-1	Hmn Proximal Type I
Infantile Muscular Atrophy	Proximal Spinal Muscular Atrophy Type 1
Sma Type 1	Sma Type I
Sma-I	Hereditary Motor Neuropathy Proximal Type I
Progressive Muscular Atrophy Of Infancy	Proximal Spinal Muscular Atrophy, Type 1
Werdnig Hoffmann Disease	Infantile Spinal Muscular Atrophy
Infantile-Onset Spinal Muscular Atrophy	Proximal Hereditary Motor Neuropathy Type I
Sma Infantile Acute Form	Spinal Muscular Atrophy Type I
Werdnig-Hoffman Disease	Atrophy, Muscular, Spinal, Type 1

Spinal Muscular Atrophy, Type Iii

SMA3	Juvenile Spinal Muscular Atrophy
Kugelberg-Welander Disease	Sma Iii
Kugelberg-Welander Syndrome	Kws
Muscular Atrophy, Juvenile	Spinal Muscular Atrophy, Mild Childhood And Adolescent Form
Spinal Muscular Atrophy-3	Spinal Muscular Atrophy Type 3
Spinal Muscular Atrophy, Type Iii, Modifier Of	Type Iii Spinal Muscular Atrophy
Sma 3	Proximal Spinal Muscular Atrophy Type 3
Sma Type 3	Sma Type Iii
Sma-Iii	Spinal Muscular Atrophy 3
Spinal Muscular Atrophy Mild Childhood And Adolescent Form	Spinal Muscular Atrophy Type Iii
Wohlfart-Kugelberg-Welander Disease	Atrophy, Muscular, Spinal, Type Iii

Childhood Spinal Muscular Atrophy

Spinal Muscular Atrophies Of Childhood

Survival Motor Neuron Spinal Muscular Atrophy

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-102020	RG3039	Inhibitor	99.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108599	DCP-LA		≥98.0%	Unkown
HY-138147	DCP-Rho1		/	Unkown
HY-155771	1-DCP		/	Unkown
HY-RS03584	DCP1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03585	DCP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03586	DCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03587	DCPS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-122604	PF-DcpSi		/	Unkown
HY-131933	DCP-Bio3		/	Unkown
HY-W087905	2,3-Dimethyl-2,3-diphenylbutane		≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCPS	RGD	RGD:628887
Mus musculus	DCPS	MGD	MGI:1916555
Macaca mulatta	DCPS	VGNC	VGNC:71816
Felis catus	DCPS	VGNC	VGNC:61375
Canis familiaris	DCPS	VGNC	VGNC:39811
Bos taurus	DCPS	VGNC	VGNC:27922

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