Rnf4 - ring finger protein 4 Gene

Rattus norvegicus

Gene ID: 29274 | Gene type: protein coding

About Rnf4

Summary

Enables several functions, including SUMO polymer binding activity; TBP-class protein binding activity; and nuclear receptor binding activity. Involved in several processes, including cellular response to gamma radiation; cellular response to hydroxyurea; and protein ubiquitination. Located in cytosol and nucleoplasm. Colocalizes with PML body. Orthologous to human RNF4 (ring finger protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rnf4 Products(1)

mRNA	Protein	Name
NM_019182.2	NP_062055.1	E3 ubiquitin-protein ligase RNF4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11319220	RGD
enables SUMO polymer binding	IDA IDA: Inferred from direct assay	18408734	RGD
enables SUMO polymer binding	IPI IPI: Inferred from physical interaction	18408734	RGD
enables TBP-class protein binding	IDA IDA: Inferred from direct assay	9710597	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	21857666	RGD
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	9710597	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	9710597	RGD
enables nucleosome binding	IDA IDA: Inferred from direct assay	11319220	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20696907	RGD
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	21857666	RGD
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21857666	RGD
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18408734	RGD
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	14987998	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	21857666	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	20943951	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	11292317	RGD
involved in cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	22661230	RGD
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	22661230	RGD
involved in cellular response to testosterone stimulus	IDA IDA: Inferred from direct assay	9710597	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	12351196	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11319220	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9710597	RGD
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18408734	RGD
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	18408734	RGD
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	18408734	RGD
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	18408734	RGD
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	21857666	RGD
involved in protein autoubiquitination	IMP IMP: Inferred from mutant phenotype	14987998	RGD
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	14987998	RGD
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	20943951	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14749358	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	14749358	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12351196	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	20943951	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	20943951	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11319220	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF4

E3 ubiquitin ligase RNF4	RING-type E3 ubiquitin transferase RNF4
SNURF	small nuclear ring finger protein

Rnf4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rnf4	O88846	APEX1	Homo sapiens	P27695	Anti Tag CoIP	20696907
Intra	Rnf4	O88846	TDG	Homo sapiens	Q13569	Anti Tag CoIP	20696907
Intra	Rnf4	O88846	SUMO2	Homo sapiens	P61956	Pull Down	21252943
Intra	Rnf4	O88846	PARP1	Homo sapiens	P09874	Anti Bait CoIP	19779455
Intra	Rnf4	O88846	TRIM28	Homo sapiens	Q13263	Pull Down	21252943
Intra	Rnf4	O88846	Rnf4	Rattus norvegicus	O88846	FRET	21857666
Intra	Rnf4	O88846	Rnf4	Rattus norvegicus	O88846	Solution Sedimentation	21857666
Intra	Rnf4	O88846	SUMO3	Homo sapiens	P55854	Pull Down	21857666
Intra	Rnf4	O88846	Rnf4	Rattus norvegicus	O88846	X-Ray Diffraction	21857666
Intra	Rnf4	O88846	Rnf4	Rattus norvegicus	O88846	GMS	21857666
Intra	Rnf4	O88846	ubiq_human	Homo sapiens	DIP-24261N	Pull Down	21857666
Cross	Rnf4	O88846	UBE2D1	Homo sapiens	P51668	Pull Down	21857666
Intra	Rnf4	O88846	UHRF1	Homo sapiens	Q96T88	Pull Down	21252943
Intra	Rnf4	O88846	RPS27A	Bos taurus	P62990	Pull Down	21857666

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143346	CCW16		98.63%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf4	NCBI	NCBI:6047
Canis familiaris	Rnf4	NCBI	NCBI:100855762
Mus musculus	Rnf4	NCBI	NCBI:19822

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