SUMO2 - small ubiquitin like modifier 2 Gene

Homo sapiens

Also known as HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2

Gene ID: 6613 | Gene type: protein coding

About SUMO2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,165,586-75,182,959 (from NCBI)

This gene has 3 transcripts (splice variants), 128 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 121.8), lymph node (RPKM 108.7) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, Apoptosis, and protein stability. It is not active until the last two Amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SUMO2 Products(2)

mRNA	Protein	Name
NM_001005849.2	NP_001005849.1	small ubiquitin-related modifier 2 isoform b precursor
NM_006937.4	NP_008868.3	small ubiquitin-related modifier 2 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18408734	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18408734	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	17081986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	22406621	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21965678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMO2 Protein Structure

Rad60-SLD

0
95 a.a.

Protein Preferred Names

Protein Names

small ubiquitin-related modifier 2

SMT3 homolog 2

SUMO2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUMO2	P61956	USP25	Homo sapiens	Q9UHP3	Y2H Array	25416956
Intra	SUMO2	P61956	USP25	Homo sapiens	Q9UHP3	Y2H Array	32296183
Intra	SUMO2	P61956	USP25	Homo sapiens	Q9UHP3	Validated Y2H	25416956
Intra	SUMO2	P61956	USP25	Homo sapiens	Q9UHP3	Validated Y2H	32296183
Intra	SUMO2	P61956	USP25	Homo sapiens	Q9UHP3	Y2H Prey Pooling	32296183
Intra	SUMO2	P61956	USPL1	Homo sapiens	Q5W0Q7	Y2H	21988832
Intra	SUMO2	P61956	USPL1	Homo sapiens	Q5W0Q7	Anti Tag CoIP	22878415
Intra	SUMO2	P61956	ZBTB33	Homo sapiens	Q86T24	Validated Y2H	32296183
Intra	SUMO2	P61956	ZBTB33	Homo sapiens	Q86T24	Y2H Prey Pooling	32296183
Intra	SUMO2	P61956	ZBTB33	Homo sapiens	Q86T24	Y2H Array	32296183
Intra	SUMO2	P61956	SENP1	Homo sapiens	Q9P0U3	Enzymatic Study	17099698
Intra	SUMO2	P61956	SENP1	Homo sapiens	Q9P0U3	Validated Y2H	32296183
Intra	SUMO2	P61956	TANK	Homo sapiens	Q92844	Pull Down	21212807
Intra	SUMO2	P61956	PIAS4	Homo sapiens	Q8N2W9	Y2H	15383276
Intra	SUMO2	P61956	PIAS4	Homo sapiens	Q8N2W9	Pull Down	15383276
Intra	SUMO2	P61956	CHD3	Homo sapiens	Q12873	Y2H	21900206
Intra	SUMO2	P61956	CHD3	Homo sapiens	Q12873	Y2H Pooling	16169070
Intra	SUMO2	P61956	SP100	Homo sapiens	P23497-2	Y2H Array	32296183
Intra	SUMO2	P61956	SP100	Homo sapiens	P23497-2	Y2H Prey Pooling	32296183
Intra	SUMO2	P61956	SENP2	Homo sapiens	Q9HC62	Validated Y2H	25416956
Intra	SUMO2	P61956	SENP2	Homo sapiens	Q9HC62	Y2H Prey Pooling	25416956
Intra	SUMO2	P61956	SENP2	Homo sapiens	Q9HC62	Y2H Array	25416956
Intra	SUMO2	P61956	PELP1	Homo sapiens	Q8IZL8	Pull Down	21326211
Intra	SUMO2	P61956	ZNF496	Homo sapiens	Q96IT1	Y2H Prey Pooling	32296183
Intra	SUMO2	P61956	ZNF496	Homo sapiens	Q96IT1	Validated Y2H	32296183
Intra	SUMO2	P61956	ZNF496	Homo sapiens	Q96IT1	Y2H Array	32296183
Intra	SUMO2	P61956	UBE2I	Homo sapiens	P63279	Sumoylase Assay	18063693
Intra	SUMO2	P61956	ZBTB39	Homo sapiens	O15060	Y2H Array	32296183
Intra	SUMO2	P61956	ZBTB39	Homo sapiens	O15060	Y2H Prey Pooling	32296183
Cross	SUMO2	P61956	uspl1	Danio rerio	Q6DRC5	Comigration in Gel	22878415
Cross	SUMO2	P61956	uspl1	Danio rerio	Q6DRC5	Enzymatic Study	22878415

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SUMO2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70974	SUMO2 Protein, Human (His)	AAH08450.1 (M1-G93)	≥95%

Related Diseases

Diseases

Alias

Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108702	ML-792	Inhibitor	99.90%	Unkown
HY-RS14026	SUMO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUMO2	RGD	RGD:621761
Mus musculus	SUMO2	MGD	MGI:2158813
Others	SUMO2	NCBI

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