Pak1 - p21 (RAC1) activated kinase 1 Gene

Rattus norvegicus

Gene ID: 29431 | Gene type: protein coding

About Pak1

Primary_assembly 1: 152,111,188-152,226,383 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 216 orthologues, 36 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 Products(1)

mRNA	Protein	Name
NM_017198.2	NP_058894.1	serine/threonine-protein kinase PAK 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11895474	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	15542607	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18054038	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12237306	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	8702668	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	20395366	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	20395366	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	22082674	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	9451000	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	23453953	RGD
involved in positive regulation of fibroblast migration	IDA IDA: Inferred from direct assay	18931661	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25199455	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23453953	RGD
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	25199455	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	19901155	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19901155	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	15542607	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12237306	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18347024	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	9367856	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	14670848	RGD
located in axon	IDA IDA: Inferred from direct assay	17687038	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17687038	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	14670848	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	19574218	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	14670848	RGD
located in ruffle	IDA IDA: Inferred from direct assay	19574218	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak1 Protein Structure

PBD

STKc_PAK1

0
100
200
300
400
500
544 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 1

PAK-1	alpha-PAK
p21 (CDKN1A)-activated kinase 1	p21 protein (Cdc42/Rac)-activated kinase 1
p21-activated kinase 1	p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
p68-PAK	protein kinase MUK2

Pak1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Pak1	P35465	Vim	Mus musculus	P20152	Protein Kinase Assay	11895474

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12005	Fingolimod hydrochloride	Activator	99.95%	Yes
HY-15027	5-Aminosalicylic Acid	Inhibitor	99.82%	Unkown
HY-11063	Fingolimod	Activator	99.97%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Phase 1
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15663	IPA-3	Inhibitor	99.43%	Unkown
HY-15542A	FRAX597	Inhibitor	99.36%	Unkown
HY-15542B	FRAX486	Inhibitor	98.01%	Unkown
HY-19635	G-5555	Inhibitor	99.88%	Unkown
HY-120940	AZ13705339	Inhibitor	98.90%	Unkown
HY-19538	FRAX1036	Inhibitor	99.49%	Unkown
HY-19635A	G-5555 hydrochloride	Inhibitor	98.26%	Unkown
HY-131043	NVS-PAK1-C	Inhibitor	99.2%	Unkown
HY-120940A	AZ13705339 hemihydrate	Inhibitor	99.77%	Unkown
HY-146783	ZINC194100678	Inhibitor	/	Unkown
HY-116917	G-9791	Inhibitor	/	Unkown
HY-159897	PAK4-IN-5	Inhibitor	/	Unkown
HY-146681	PAK1-IN-1	Inhibitor	/	Unkown
HY-131265	Mesalamine impurity P	Inhibitor	/	Unkown
HY-110085	2,2′-Dihydroxy-6,6′-dinaphthyl disulfide	Inhibitor	/	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown
HY-164374	AK963/40708899	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak1	NCBI	NCBI:5058

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