2. Gene
  3. PAK1 - p21 (RAC1) activated kinase 1 Gene

PAK1 - p21 (RAC1) activated kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IDDMSSD; p65-PAK; PAKalpha; alpha-PAK

Gene ID: 5058 | Gene type: protein coding

About PAK1

Cytogenetic location: 11q13.5-q14.1 Genomic coordinates (GRCh38): 11:77,322,017-77,530,009 (from NCBI)

This gene has 20 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues.

Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to Cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many Cancer types, and particularly in breast Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]

PAK1 Products(50)

mRNA Protein Name
NM_001376294.1 NP_001363223.1 serine/threonine-protein kinase PAK 1 isoform 8
NM_001376272.1 NP_001363201.1 serine/threonine-protein kinase PAK 1 isoform 3
NM_001376305.1 NP_001363234.1 serine/threonine-protein kinase PAK 1 isoform 13
NM_001376280.1 NP_001363209.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376271.1 NP_001363200.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001376286.1 NP_001363215.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376302.1 NP_001363231.1 serine/threonine-protein kinase PAK 1 isoform 11
NM_001376292.1 NP_001363221.1 serine/threonine-protein kinase PAK 1 isoform 7
NM_001376293.1 NP_001363222.1 serine/threonine-protein kinase PAK 1 isoform 7
XM_024448558.2 XP_024304326.1 serine/threonine-protein kinase PAK 1 isoform X3
XM_047427053.1 XP_047283009.1 serine/threonine-protein kinase PAK 1 isoform X4
XM_047427054.1 XP_047283010.1 serine/threonine-protein kinase PAK 1 isoform X4
XM_047427052.1 XP_047283008.1 serine/threonine-protein kinase PAK 1 isoform X3
NR_164798.1
XM_047427046.1 XP_047283002.1 serine/threonine-protein kinase PAK 1 isoform X1
NM_001376281.1 NP_001363210.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376282.1 NP_001363211.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376285.1 NP_001363214.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376269.1 NP_001363198.1 serine/threonine-protein kinase PAK 1 isoform 1
XM_047427050.1 XP_047283006.1 serine/threonine-protein kinase PAK 1 isoform X3
NM_001376284.1 NP_001363213.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376295.1 NP_001363224.1 serine/threonine-protein kinase PAK 1 isoform 9
NM_001376270.1 NP_001363199.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001376303.1 NP_001363232.1 serine/threonine-protein kinase PAK 1 isoform 12
XM_024448557.2 XP_024304325.1 serine/threonine-protein kinase PAK 1 isoform X3
NM_001376274.1 NP_001363203.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376277.1 NP_001363206.1 serine/threonine-protein kinase PAK 1 isoform 2
XM_024448560.2 XP_024304328.1 serine/threonine-protein kinase PAK 1 isoform X4
XM_024448559.2 XP_024304327.1 serine/threonine-protein kinase PAK 1 isoform X3
XM_047427051.1 XP_047283007.1 serine/threonine-protein kinase PAK 1 isoform X3
NM_001376268.1 NP_001363197.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001376289.1 NP_001363218.1 serine/threonine-protein kinase PAK 1 isoform 5
NM_001376273.1 NP_001363202.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376290.1 NP_001363219.1 serine/threonine-protein kinase PAK 1 isoform 6
XM_047427049.1 XP_047283005.1 serine/threonine-protein kinase PAK 1 isoform X3
XM_047427047.1 XP_047283003.1 serine/threonine-protein kinase PAK 1 isoform X2
NM_001128620.2 NP_001122092.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001376279.1 NP_001363208.1 serine/threonine-protein kinase PAK 1 isoform 2
XM_047427048.1 XP_047283004.1 serine/threonine-protein kinase PAK 1 isoform X3
NM_001376291.1 NP_001363220.1 serine/threonine-protein kinase PAK 1 isoform 6
NM_001376288.1 NP_001363217.1 serine/threonine-protein kinase PAK 1 isoform 4
NM_001376275.1 NP_001363204.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376304.1 NP_001363233.1 serine/threonine-protein kinase PAK 1 isoform 13
NM_001376283.1 NP_001363212.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376276.1 NP_001363205.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376301.1 NP_001363230.1 serine/threonine-protein kinase PAK 1 isoform 10
NM_002576.5 NP_002567.3 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376287.1 NP_001363216.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001376278.1 NP_001363207.1 serine/threonine-protein kinase PAK 1 isoform 2
NR_164797.1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables collagen binding IPI
IPI: Inferred from physical interaction
12189148 GOA
enables gamma-tubulin binding IDA
IDA: Inferred from direct assay
27012601 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17389360 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10026169 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
8805275 GOA
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
10559936 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
16278681 GOA
contributes to small GTPase binding IPI
IPI: Inferred from physical interaction
11950598 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23260667 GOA
NOT involved in MAPK cascade IDA
IDA: Inferred from direct assay
8805275 GOA
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
9395435 GOA
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
27917469 GOA
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16278681 GOA
involved in branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
20457839 GOA
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
27917469 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
23260667 GOA
involved in hepatocyte growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25198505 GOA
involved in negative regulation of cell proliferation involved in contact inhibition IMP
IMP: Inferred from mutant phenotype
12912914 GOA
involved in phosphorylation IDA
IDA: Inferred from direct assay
27012601 GOA
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
8805275 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
25766321 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23333386 GOA
involved in positive regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
16278681 GOA
involved in positive regulation of microtubule nucleation IMP
IMP: Inferred from mutant phenotype
27012601 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
25198505 GOA
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19667065 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23633677 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
11864573 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8805275 GOA
involved in protein localization to cytoplasmic stress granule IDA
IDA: Inferred from direct assay
20417602 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9852149 GOA
involved in wound healing IMP
IMP: Inferred from mutant phenotype
12912914 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IDA
IDA: Inferred from direct assay
9395435 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
12912914 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16278681 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
23260667 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16278681 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
11864573 GOA
located in ruffle IDA
IDA: Inferred from direct assay
12912914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK1 Protein Structure

PBD

PBD: P21-Rho-binding domain (74 - 132)

Pkinase

Pkinase: Protein kinase domain (270 - 521)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 1

STE20 homolog, yeast

p21 protein (Cdc42/Rac)-activated kinase 1

p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

PAK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PAK1 Q13153 TTC12 Homo sapiens Q9H892-2
Y2H Pooling
32814053
Intra
PAK1 Q13153 TTC12 Homo sapiens Q9H892-2
Validated Y2H
32814053
Intra
PAK1 Q13153 TTC12 Homo sapiens Q9H892-2
Y2H Array
32814053
Intra
PAK1 Q13153 GIT2 Homo sapiens Q14161
Anti Tag CoIP
35271311
Intra
PAK1 Q13153 GIT2 Homo sapiens Q14161
Anti Tag CoIP
31980649
Intra
PAK1 Q13153 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32814053
Intra
PAK1 Q13153 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Pooling
32814053
Intra
PAK1 Q13153 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Array
32814053
Intra
PAK1 Q13153 GRB10 Homo sapiens Q13322-4
Y2H Pooling
32814053
Intra
PAK1 Q13153 GRB10 Homo sapiens Q13322-4
Validated Y2H
32814053
Intra
PAK1 Q13153 GRB10 Homo sapiens Q13322-4
Y2H Array
32814053
Intra
PAK1 Q13153 CDK11B Homo sapiens P21127
Y2H
12624090
Intra
PAK1 Q13153 CDK11B Homo sapiens P21127
Anti Tag CoIP
12624090
Intra
PAK1 Q13153 CDK11B Homo sapiens P21127
Pull Down
12624090
Intra
PAK1 Q13153 CDK11B Homo sapiens P21127
Anti Tag CoIP
16413544
Intra
PAK1 Q13153 ARHGEF6 Homo sapiens Q15052
TAP
23455922
Intra
PAK1 Q13153 ARHGEF6 Homo sapiens Q15052
Anti Tag CoIP
35271311
Intra
PAK1 Q13153 ARHGEF6 Homo sapiens Q15052
Anti Tag CoIP
31980649
Intra
PAK1 Q13153 TIMM17B Homo sapiens O60830
Y2H Array
32814053
Intra
PAK1 Q13153 TIMM17B Homo sapiens O60830
Y2H Pooling
32814053
Intra
PAK1 Q13153 TIMM17B Homo sapiens O60830
Validated Y2H
32814053
Intra
PAK1 Q13153 ZHX1-C8orf76 Homo sapiens Q96EF9
Y2H Array
32814053
Intra
PAK1 Q13153 ZHX1-C8orf76 Homo sapiens Q96EF9
Y2H Pooling
32814053
Intra
PAK1 Q13153 ZHX1-C8orf76 Homo sapiens Q96EF9
Validated Y2H
32814053
Intra
PAK1 Q13153 ADD1 Homo sapiens P35611
Validated Y2H
32814053
Intra
PAK1 Q13153 ADD1 Homo sapiens P35611
Y2H Array
32814053
Intra
PAK1 Q13153 ADD1 Homo sapiens P35611
Y2H Pooling
32814053
Intra
PAK1 Q13153 ACP2 Homo sapiens P11117
Validated Y2H
32814053
Intra
PAK1 Q13153 ACP2 Homo sapiens P11117
Y2H Array
32814053
Intra
PAK1 Q13153 ACP2 Homo sapiens P11117
Y2H Pooling
32814053
Intra
PAK1 Q13153 MAPK11 Homo sapiens Q15759
Y2H Pooling
32814053
Intra
PAK1 Q13153 MAPK11 Homo sapiens Q15759
Validated Y2H
32814053
Intra
PAK1 Q13153 MAPK11 Homo sapiens Q15759
Y2H Array
32814053
Intra
PAK1 Q13153 DYNLL1 Homo sapiens P63167
Validated Y2H
32814053
Intra
PAK1 Q13153 DYNLL1 Homo sapiens P63167
Y2H Pooling
32814053
Intra
PAK1 Q13153 DYNLL1 Homo sapiens P63167
Y2H Array
32814053
Intra
PAK1 Q13153 DYNLL1 Homo sapiens P63167
Y2H
21988832
Intra
PAK1 Q13153 b3kx85_human Homo sapiens B3KX85
Y2H
16278681
Intra
PAK1 Q13153 RIT1 Homo sapiens Q92963
Confocal
29734338
Intra
PAK1 Q13153 RIT1 Homo sapiens Q92963
Anti Bait CoIP
29734338
Intra
PAK1 Q13153 TCP10L Homo sapiens Q8TDR4
Y2H Array
32814053
Intra
PAK1 Q13153 TCP10L Homo sapiens Q8TDR4
Y2H Pooling
32814053
Intra
PAK1 Q13153 TCP10L Homo sapiens Q8TDR4
Validated Y2H
32814053
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
21167153
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
21454543
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
26175416
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
19270716
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
25843002
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
FRET
11030651
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
24172987
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
12879077
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
24625804
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
16492808
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
24792722
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
17245428
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Anti Tag CoIP
20810653
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000
Pull Down
21029865
Cross
PAK1 Q13153 Rac1 Mus musculus P63001
Pull Down
19893577
Cross
PAK1 Q13153 Rac1 Mus musculus P63001
Pull Down
18854161
Cross
PAK1 Q13153 Rac1 Mus musculus P63001
Pull Down
18325335
Intra
PAK1 Q13153 LIMK1 Homo sapiens P53667
Protein Kinase Assay
10559936
Intra
PAK1 Q13153 LIMK1 Homo sapiens P53667
Anti Bait CoIP
10559936
Intra
PAK1 Q13153 LIMK1 Homo sapiens P53667
IF
10559936
Intra
PAK1 Q13153 GIT1 Homo sapiens Q9Y2X7
Anti Tag CoIP
31980649
Intra
PAK1 Q13153 GIT1 Homo sapiens Q9Y2X7
TAP
23455922
Intra
PAK1 Q13153 GIT1 Homo sapiens Q9Y2X7
Anti Tag CoIP
25852190
Intra
PAK1 Q13153 NOTCH1 Homo sapiens P46531
Anti Bait CoIP
33189893
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
Anti Tag CoIP
31980649
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
Y2H Array
31515488
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
Anti Tag CoIP
35271311
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
PAK1 Q13153 NCK2 Homo sapiens O43639
TAP
23455922
Intra
PAK1 Q13153 STX11 Homo sapiens O75558
Validated Y2H
32814053
Intra
PAK1 Q13153 STX11 Homo sapiens O75558
Y2H Array
32814053
Intra
PAK1 Q13153 STX11 Homo sapiens O75558
Y2H Pooling
32814053
Intra
PAK1 Q13153 KLHL20 Homo sapiens Q9Y2M5
Y2H Pooling
32814053
Intra
PAK1 Q13153 KLHL20 Homo sapiens Q9Y2M5
Validated Y2H
32814053
Intra
PAK1 Q13153 KLHL20 Homo sapiens Q9Y2M5
Y2H Array
32814053
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
BRET
29997244
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Lumier
32814053
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Fluorescence Spectr
16101281
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Anti Bait CoIP
16628223
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
TAP
23455922
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Pull Down
16492808
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Anti Tag CoIP
31980649
Intra
PAK1 Q13153 ARHGEF7 Homo sapiens Q14155
Anti Bait CoIP
16407834
Intra
PAK1 Q13153 RAC1 Homo sapiens P63000-1
Pull Down
25150978
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Pull Down
12879077
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Pull Down
7744004
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Anti Tag CoIP
12606577
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Imaging
7744004
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Pull Down
21167153
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Pull Down
21029865
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
Pull Down
23175184
Intra
PAK1 Q13153 CDC42 Homo sapiens P60953
TAP
23455922
Cross
PAK1 Q13153 Cdc42 Mus musculus P60766
Pull Down
18325335
Cross
PAK1 Q13153 Cdc42 Mus musculus P60766
Pull Down
19893577
Intra
PAK1 Q13153 OTX2 Homo sapiens P32243-2
Validated Y2H
32814053
Intra
PAK1 Q13153 OTX2 Homo sapiens P32243-2
Y2H Pooling
32814053
Intra
PAK1 Q13153 OTX2 Homo sapiens P32243-2
Y2H Array
32814053
Intra
PAK1 Q13153 SEMA4G Homo sapiens Q9NTN9-3
Validated Y2H
32814053
Intra
PAK1 Q13153 SEMA4G Homo sapiens Q9NTN9-3
Y2H Array
32814053
Intra
PAK1 Q13153 SEMA4G Homo sapiens Q9NTN9-3
Y2H Pooling
32814053
Intra
PAK1 Q13153 TCAP Homo sapiens O15273
Y2H Array
32814053
Intra
PAK1 Q13153 TCAP Homo sapiens O15273
Validated Y2H
32814053
Intra
PAK1 Q13153 TCAP Homo sapiens O15273
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK1 Proteins

Cat. No. Product Name Accession Purity
HY-P71530 PAK1 Protein, Human (His-SUMO) Q13153-1 (M1-H545) ≥95%

PAK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81618 PAK1 Antibody (YA1363) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2

CGD2

Ncf2 Deficiency

P67-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii

Granulomatous Disease, Chronic, Due To Ncf2 Deficiency

Neutrophil Cytosol Factor 2 Deficiency

Chronic Granulomatous Disease 2, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 2

Cdg2

Deficiency Of Ncf2

Deficiency Of P67-Phox

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii

Deficiency Of Neutrophil Cytosol Factor 2

Avellino Corneal Dystrophy
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Neurofibromatosis

Neurofibromatoses

Acoustic Neurofibromatosis

Central Neurofibromatosis

Peripheral Neurofibromatosis

Recklinghausen'S Neurofibromatosis

Von Reklinghausen Disease

Neurofibromatosis Type 1
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay

IDDMSSD
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Prolapse Of Urethra

Urethrocele
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12005 Fingolimod hydrochloride Activator 99.95% Yes
HY-15027 5-Aminosalicylic Acid Inhibitor 99.82% Unkown
HY-11063 Fingolimod Activator 99.97% Yes
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.84% Phase 1
HY-13007B PF-3758309 dihydrochloride Inhibitor / Phase 1
HY-13007A PF-3758309 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15663 IPA-3 Inhibitor 99.43% Unkown
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.01% Unkown
HY-19635 G-5555 Inhibitor 99.88% Unkown
HY-120940 AZ13705339 Inhibitor 98.90% Unkown
HY-19538 FRAX1036 Inhibitor 99.49% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.26% Unkown
HY-131043 NVS-PAK1-C Inhibitor 99.2% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-146783 ZINC194100678 Inhibitor / Unkown
HY-116917 G-9791 Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-131265 Mesalamine impurity P Inhibitor / Unkown
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-164374 AK963/40708899 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAK1 MGD MGI:1339975
Canis familiaris PAK1 VGNC VGNC:52285
Felis catus PAK1 VGNC VGNC:81962
Bos taurus PAK1 VGNC VGNC:53657
Rattus norvegicus PAK1 RGD RGD:3250
Macaca mulatta PAK1 VGNC VGNC:101373
Others PAK1 NCBI