GTF2F1 - general transcription factor IIF subunit 1 Gene

Homo sapiens

Also known as BTF4; RAP74; TF2F1; TFIIF

Gene ID: 2962 | Gene type: protein coding

About GTF2F1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,379,572-6,393,164 (from NCBI)

This gene has 6 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in ovary (RPKM 36.8), testis (RPKM 30.9) and 25 other tissues.

Summary

Enables several functions, including RNA polymerase II general transcription initiation factor activity; Phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; response to virus; and transcription initiation from RNA polymerase II promoter. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF2F1 Products(1)

mRNA	Protein	Name
NM_002096.3	NP_002087.2	general transcription factor IIF subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	7929273	GOA
enables RNA polymerase II general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8625415	GOA
enables phosphatase activator activity	IDA IDA: Inferred from direct assay	12721286	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	24441171	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7590250	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15723517	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	12732728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	8662660	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15351637	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8662660	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	15351637	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7929273	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	15723517	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	12732728	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA
part of transcription factor TFIIF complex	IPI IPI: Inferred from physical interaction	11183778	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2F1 Protein Structure

TFIIF_alpha

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

general transcription factor IIF subunit 1

TFIIF-alpha

GTF2F1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	TAP	24981860
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	Complementation	31467278
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	BRET	37398436
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	Lumier	37398436
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	MAPPIT	31467278
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	Y2H	7854423
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	SLC	31467278
Intra	GTF2F1	P35269	GTF2F2	Homo sapiens	P13984	X-Ray Diffraction	11183778
Intra	GTF2F1	P35269	CTDP1	Homo sapiens	Q9Y5B0	NMR	12732728
Intra	GTF2F1	P35269	URI1	Homo sapiens	O94763	Far-WB	12737519
Intra	GTF2F1	P35269	URI1	Homo sapiens	O94763	Anti Tag CoIP	12737519
Intra	GTF2F1	P35269	TAF1	Homo sapiens	P21675	Anti Tag CoIP	7590250
Intra	GTF2F1	P35269	TAF1	Homo sapiens	P21675	CoIP	7590250

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05896	GTF2F1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GTF2F1	RGD	RGD:1359646
Bos taurus	GTF2F1	VGNC	VGNC:97277
Canis familiaris	GTF2F1	VGNC	VGNC:41546
Macaca mulatta	GTF2F1	VGNC	VGNC:73309
Felis catus	GTF2F1	VGNC	VGNC:67497
Mus musculus	GTF2F1	MGD	MGI:1923848

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