USP25 - ubiquitin specific peptidase 25 Gene

Homo sapiens

Also known as USP21

Gene ID: 29761 | Gene type: protein coding

About USP25

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:15,729,982-15,880,064 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 20.1), endometrium (RPKM 11.0) and 25 other tissues.

Summary

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

USP25 Products(9)

mRNA	Protein	Name
NM_001283041.3	NP_001269970.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m
NM_001283042.3	NP_001269971.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25b
NM_001352560.2	NP_001339489.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001352561.2	NP_001339490.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388299.1	NP_001375228.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001388300.1	NP_001375229.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388301.1	NP_001375230.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388302.1	NP_001375231.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 6
NM_013396.6	NP_037528.3	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	22590560	GOA
enables SUMO binding	IPI IPI: Inferred from physical interaction	18538659	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	18538659	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	23042150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18538659	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22590560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	22590560	GOA
involved in negative regulation of interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	23042150	GOA
involved in negative regulation of response to oxidative stress	IDA IDA: Inferred from direct assay	37339955	GOA
involved in protein K48-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	18538659	GOA
involved in protein K63-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	18538659	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	22590560	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	2304215	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22590560	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP25 Protein Structure

UIM

UCH

0
200
400
600
800
1000
1055 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 25

USP on chromosome 21

USP25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP25	Q9UHP3	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	USP25	Q9UHP3	TNKS2	Homo sapiens	Q9H2K2	Y2H Fragment Pooling	35914814
Intra	USP25	Q9UHP3	SUMO2	Homo sapiens	P61956	Y2H Prey Pooling	25416956
Intra	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
Intra	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
Intra	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
Intra	USP25	Q9UHP3	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	25416956
Intra	USP25	Q9UHP3	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	25416956
Intra	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	31515488
Intra	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	25416956
Intra	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	USP25	Q9UHP3	MAGEB4	Homo sapiens	O15481	Validated Y2H	25416956
Intra	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Y2H	21516116
Intra	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Validated Y2H	25416956
Intra	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Y2H Array	25416956
Intra	USP25	Q9UHP3	GDI1	Homo sapiens	P31150	Y2H Fragment Pooling	35914814
Intra	USP25	Q9UHP3	RAD23B	Homo sapiens	P54727	Y2H Fragment Pooling	35914814

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Arthrogryposis, Renal Dysfunction, And Cholestasis 2

ARCS2	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 2
Arthrogryposis Renal Dysfunction And Cholestasis 2

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117370	USP25/28 inhibitor AZ1	Inhibitor	≥98.0%	Unkown
HY-153996	CT1113	Inhibitor	/	Unkown
HY-RS15535	USP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP25	RGD	RGD:1309003
Felis catus	USP25	VGNC	VGNC:66875
Mus musculus	USP25	MGD	MGI:1353655
Canis familiaris	USP25	VGNC	VGNC:48184
Bos taurus	USP25	VGNC	VGNC:36718
Macaca mulatta	USP25	VGNC	VGNC:78744
Others	USP25	NCBI

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