2. Gene
  3. TNKS2 - tankyrase 2 Gene

TNKS2 - tankyrase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c

Gene ID: 80351 | Gene type: protein coding

About TNKS2

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,798,426-91,865,475 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; Enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 Products(6)

mRNA Protein Name
XM_011540213.2 XP_011538515.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X1
XM_047425795.1 XP_047281751.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_017016701.2 XP_016872190.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X4
NM_025235.4 NP_079511.1 poly [ADP-ribose] polymerase tankyrase-2
XM_017016699.2 XP_016872188.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X2
XM_017016700.3 XP_016872189.2 poly [ADP-ribose] polymerase tankyrase-2 isoform X3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
11739745 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
19759537 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21251231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11854288 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19759537 GOA
involved in positive regulation of telomere capping IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
21478859 GOA
involved in protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
11739745 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19759537 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11278563 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
11454873 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11739745 GOA
located in pericentriolar material IDA
IDA: Inferred from direct assay
11454873 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11454873 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS2 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (28 - 121)

Ank

Ank: Ankyrin repeat (125 - 154)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (215 - 305)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (338 - 429)

Ank

Ank: Ankyrin repeat (433 - 461)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (496 - 589)

Ank_4

Ank_4: Ankyrin repeats (many copies) (594 - 631)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (683 - 775)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (877 - 933)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (955 - 1156)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1166 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-2

ADP-ribosyltransferase diphtheria toxin-like 6

TNKS-2

TRF1-interacting ankyrin-related ADP-ribose polymerase 2

poly [ADP-ribose] polymerase 5B

protein poly-ADP-ribosyltransferase tankyrase-2

tankyrase II

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

tankyrase-like protein

tankyrase-related protein

Related Diseases

Diseases Alias
Cherubism

CRBM

Familial Benign Giant-Cell Tumor Of The Jaw

Familial Fibrous Dysplasia Of Jaw

Familial Multilocular Cystic Disease Of The Jaws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13990 NVP-TNKS656 99.66% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-12975 AZ6102 Inhibitor 99.65% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-145267 OM-153 Inhibitor 99.59% Unkown
HY-148063 DB0614 98.80% Unkown
HY-123851 MSC2504877 Inhibitor 98.50% Unkown
HY-15811 XMD8-87 Inhibitor 98.15% Unkown
HY-101243 XMD16-5 Inhibitor 98.59% Unkown
HY-148061 DB1113 99.28% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-121719 TIQ-A Inhibitor 99.65% Unkown
HY-126248 Tankyrase-IN-2 Inhibitor 99.06% Unkown
HY-147886 PARP1-IN-11 Inhibitor 98.58% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-145266 OM-1700 Inhibitor / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.77% Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TNKS2 VGNC VGNC:66423
Bos taurus TNKS2 VGNC VGNC:36186
Mus musculus TNKS2 MGD MGI:1921743
Rattus norvegicus TNKS2 RGD RGD:1305026
Canis familiaris TNKS2 VGNC VGNC:47683
Macaca mulatta TNKS2 VGNC VGNC:78983