TNKS2 - tankyrase 2 Gene

Homo sapiens

Also known as TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c

Gene ID: 80351 | Gene type: protein coding

About TNKS2

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,798,426-91,865,475 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; Enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 Products(6)

mRNA	Protein	Name
XM_011540213.2	XP_011538515.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X1
XM_047425795.1	XP_047281751.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_017016701.2	XP_016872190.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X4
NM_025235.4	NP_079511.1	poly [ADP-ribose] polymerase tankyrase-2
XM_017016699.2	XP_016872188.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X2
XM_017016700.3	XP_016872189.2	poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	11739745	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	19759537	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21251231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11854288	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	25939383	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19759537	GOA
involved in positive regulation of telomere capping	IMP IMP: Inferred from mutant phenotype	25939383	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	21478859	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	11739745	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	19759537	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11278563	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	11454873	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11739745	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	11454873	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11454873	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS2 Protein Structure

Ank_2

Ank

Ank_2

Ank

Ank_2

Ank_4

Ank_2

SAM_2

PARP

0
200
400
600
800
1000
1166 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase tankyrase-2

ADP-ribosyltransferase diphtheria toxin-like 6	TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2	poly [ADP-ribose] polymerase 5B
protein poly-ADP-ribosyltransferase tankyrase-2	tankyrase II
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	tankyrase-like protein
tankyrase-related protein

TNKS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNKS2	Q9H2K2	STRN	Homo sapiens	O43815	Pull Down	22153077
Intra	TNKS2	Q9H2K2	ARPIN	Homo sapiens	Q7Z6K5-1	X-Ray Diffraction	26774128
Intra	TNKS2	Q9H2K2	ARPIN	Homo sapiens	Q7Z6K5-1	SAXS	26774128
Intra	TNKS2	Q9H2K2	ARPIN	Homo sapiens	Q7Z6K5-1	ITC	26774128
Intra	TNKS2	Q9H2K2	ARPIN	Homo sapiens	Q7Z6K5-1	GMS	26774128
Intra	TNKS2	Q9H2K2	TNKS1BP1	Homo sapiens	Q9C0C2	Pull Down	12080061
Intra	TNKS2	Q9H2K2	TNKS1BP1	Homo sapiens	Q9C0C2	FPS	22153077
Intra	TNKS2	Q9H2K2	USP25	Homo sapiens	Q9UHP3	FPS	22153077
Intra	TNKS2	Q9H2K2	LNPEP	Homo sapiens	Q9UIQ6	Pull Down	12080061
Intra	TNKS2	Q9H2K2	LNPEP	Homo sapiens	Q9UIQ6	FPS	22153077
Intra	TNKS2	Q9H2K2	ANKRD28	Homo sapiens	O15084	Y2H Fragment Pooling	23414517
Intra	TNKS2	Q9H2K2	NUMA1	Homo sapiens	Q14980	Y2H	12080061
Intra	TNKS2	Q9H2K2	NUMA1	Homo sapiens	Q14980	Pull Down	12080061
Intra	TNKS2	Q9H2K2	NUMA1	Homo sapiens	Q14980	FPS	22153077
Intra	TNKS2	Q9H2K2	DISC1	Homo sapiens	Q9NRI5	FPS	22153077
Cross	TNKS2	Q9H2K2	Sh3bp2	Mus musculus	Q06649	Anti Tag CoIP	22153076
Cross	TNKS2	Q9H2K2	Sh3bp2	Mus musculus	Q06649	Pull Down	22153076
Cross	TNKS2	Q9H2K2	Sh3bp2	Mus musculus	Q06649	Pull Down	22153077
Intra	TNKS2	Q9H2K2	CACNA1S	Homo sapiens	Q13698	FPS	22153077
Intra	TNKS2	Q9H2K2	CACNA1S	Homo sapiens	Q13698	Y2H	12080061
Intra	TNKS2	Q9H2K2	HOXB2	Homo sapiens	P14652	Y2H	12080061
Intra	TNKS2	Q9H2K2	HOXB2	Homo sapiens	P14652	FPS	22153077
Intra	TNKS2	Q9H2K2	RAD54L	Homo sapiens	Q92698	Pull Down	22153077
Intra	TNKS2	Q9H2K2	AXIN1	Homo sapiens	O15169	FPS	22153077
Intra	TNKS2	Q9H2K2	TERF1	Homo sapiens	P54274	FPS	22153077
Intra	TNKS2	Q9H2K2	TERF1	Homo sapiens	P54274	Pull Down	22153077
Intra	TNKS2	Q9H2K2	TERF1	Homo sapiens	P54274	Pull Down	12080061
Intra	TNKS2	Q9H2K2	BCR	Homo sapiens	P11274	Anti Tag CoIP	22153077
Intra	TNKS2	Q9H2K2	BCR	Homo sapiens	P11274	Pull Down	22153077
Intra	TNKS2	Q9H2K2	PPP1R12C	Homo sapiens	Q9BZL4	Y2H	12080061
Intra	TNKS2	Q9H2K2	PPP1R12C	Homo sapiens	Q9BZL4	FPS	22153077
Intra	TNKS2	Q9H2K2	SH3BP2	Homo sapiens	P78314	FPS	22153077
Intra	TNKS2	Q9H2K2	SH3BP2	Homo sapiens	P78314	Anti Bait CoIP	22153076
Intra	TNKS2	Q9H2K2	HIF1AN	Homo sapiens	Q9NWT6	Enzymatic Study	21251231
Intra	TNKS2	Q9H2K2	HIF1AN	Homo sapiens	Q9NWT6	X-Ray Diffraction	21251231
Intra	TNKS2	Q9H2K2	BABAM1	Homo sapiens	Q9NWV8	Pull Down	22153077
Intra	TNKS2	Q9H2K2	FAT4	Homo sapiens	Q6V0I7	FPS	22153077

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13990	NVP-TNKS656		99.66%	Unkown
HY-12438	G007-LK	Inhibitor	99.24%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-145267	OM-153	Inhibitor	99.59%	Unkown
HY-U00422	K-756	Inhibitor	99.25%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-15811	XMD8-87	Inhibitor	98.15%	Unkown
HY-101243	XMD16-5	Inhibitor	98.59%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.19%	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-12601	TNKS 22	Inhibitor	/	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-145266	OM-1700	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TNKS2	VGNC	VGNC:66423
Bos taurus	TNKS2	VGNC	VGNC:36186
Mus musculus	TNKS2	MGD	MGI:1921743
Rattus norvegicus	TNKS2	RGD	RGD:1305026
Canis familiaris	TNKS2	VGNC	VGNC:47683
Macaca mulatta	TNKS2	VGNC	VGNC:78983

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