TFPT - TCF3 fusion partner Gene

Homo sapiens

Also known as FB1; amida; INO80F

Gene ID: 29844 | Gene type: protein coding

About TFPT

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,107,020-54,115,657 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 109 orthologues and is associated with 46 phenotypes. Ubiquitous expression in brain (RPKM 11.2), prostate (RPKM 8.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and protein kinase binding activity. Involved in apoptotic signaling pathway. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

TFPT Products(2)

mRNA	Protein	Name
NM_001321792.2	NP_001308721.1	TCF3 fusion partner isoform 2
NM_013342.4	NP_037474.1	TCF3 fusion partner isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17395368	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17041757	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	21303910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TCF3 fusion partner

INO80 complex subunit F

TFPT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TFPT	P0C1Z6	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	33961781
Intra	TFPT	P0C1Z6	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	18922472
Intra	TFPT	P0C1Z6	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	TFIP11	Homo sapiens	Q9UBB9	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	TFPT	P0C1Z6	EAF2	Homo sapiens	Q96CJ1	Y2H	17395368
Intra	TFPT	P0C1Z6	EAF2	Homo sapiens	Q96CJ1	Anti Tag CoIP	17395368
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	Anti Tag CoIP	33961781
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	Validated Y2H	27107012
Intra	TFPT	P0C1Z6	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TRAF1	Homo sapiens	Q13077	Validated Y2H	27107012
Intra	TFPT	P0C1Z6	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	C19orf25	Homo sapiens	Q9UFG5	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	CCNDBP1	Homo sapiens	O95273	BFG-2H	27107012
Intra	TFPT	P0C1Z6	CCNDBP1	Homo sapiens	O95273	Y2H	27107012
Intra	TFPT	P0C1Z6	STK3	Homo sapiens	Q13188	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Childhood Leukemia

B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy

B-All With Hyperdiploidy

B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14429	TFPT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TFPT	VGNC	VGNC:35795
Macaca mulatta	TFPT	VGNC	VGNC:78378
Rattus norvegicus	TFPT	RGD	RGD:620839
Canis familiaris	TFPT	VGNC	VGNC:47303
Mus musculus	TFPT	MGD	MGI:1916964
Felis catus	TFPT	VGNC	VGNC:66125

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