Atm - ATM serine/threonine kinase Gene

Rattus norvegicus

Gene ID: 300711 | Gene type: protein coding

About Atm

Primary_assembly 8: 53,831,093-53,932,437 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 226 orthologues, 5 paralogues and is associated with 113 phenotypes. Biased expression in Spleen (RPKM 259.9), Thymus (RPKM 189.4) and 9 other tissues.

Summary

Predicted to enable identical protein binding activity; phosphotransferase activity, alcohol group as acceptor; and protein N-terminus binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; positive regulation of nitrogen compound metabolic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atm Products(1)

mRNA	Protein	Name
NM_001106821.1	NP_001100291.1	serine-protein kinase ATM

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	12915485	RGD
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19151707	RGD
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	28007901	RGD
involved in positive regulation of DNA catabolic process	IMP IMP: Inferred from mutant phenotype	27895165	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20502937	RGD
involved in regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	28007901	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16651613	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atm Protein Structure

TAN

FAT

PIKKc_ATM

FATC

0
500
1000
1500
2000
2500
3096 a.a.

Protein Preferred Names

Protein Names

serine-protein kinase ATM

Ataxia telangiectasia gene mutated in human beings

ataxia telangiectasia mutated homolog

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111783	AZD-7648	Inhibitor	99.86%	Phase 2
HY-139609	Camonsertib	Inhibitor	99.75%	Phase 2
HY-109566	AZD1390	Inhibitor	99.28%	Phase 1
HY-100016	AZD0156	Inhibitor	99.83%	Phase 1
HY-13902	Berzosertib	Inhibitor	99.70%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12016	KU-55933	Inhibitor	99.92%	Unkown
HY-14731	VE-821	Inhibitor	99.67%	Unkown
HY-12061	KU-60019	Inhibitor	99.43%	Unkown
HY-150617	Lartesertib	Inhibitor	99.59%	Unkown
HY-15520	CGK733	Inhibitor	99.83%	Unkown
HY-11002	CP-466722	Inhibitor	99.91%	Unkown
HY-103241	Ro 90-7501	Inhibitor	99.10%	Unkown
HY-15521	ETP-46464	Inhibitor	99.55%	Unkown
HY-112305	AZ32	Inhibitor	99.94%	Unkown
HY-112198	AZ31	Inhibitor	98.13%	Unkown
HY-112614	ATM Inhibitor-1	Inhibitor	/	Unkown
HY-141478	Antitumor agent-28	Inhibitor	/	Unkown
HY-151915	ATR-IN-20	Inhibitor	/	Unkown
HY-147567	ATR-IN-15	Inhibitor	/	Unkown
HY-144687	ATM Inhibitor-4	Inhibitor	/	Unkown
HY-144686	ATM Inhibitor-3	Inhibitor	/	Unkown
HY-144685	ATM Inhibitor-2	Inhibitor	/	Unkown
HY-169310	ATM Inhibitor-11	Inhibitor	/	Unkown
HY-149291	ATM Inhibitor-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atm	NCBI	NCBI:472

Name
Email *

	Sorry, but the email address you supplied was invalid.