2. Gene
  3. KCNIP3 - potassium voltage-gated channel interacting protein 3 Gene

KCNIP3 - potassium voltage-gated channel interacting protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CSEN; DREAM; KCHIP3

Gene ID: 30818 | Gene type: protein coding

About KCNIP3

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,297,347-95,386,077 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 14 paralogues. Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues.

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

KCNIP3 Products(2)

mRNA Protein Name
NM_001034914.2 NP_001030086.1 calsenilin isoform 2 precursor
NM_013434.5 NP_038462.1 calsenilin isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10078534 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10078534 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10078534 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP3 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (105 - 155)

EF-hand_7

EF-hand_7: EF-hand domain pair (166 - 239)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

calsenilin

A-type potassium channel modulatory protein 3

KCNIP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KCNIP3 Q9Y2W7 SOD3 Homo sapiens P08294
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 SOD3 Homo sapiens P08294
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 IL6ST Homo sapiens Q17RA0
Y2H Array
25416956
Intra
KCNIP3 Q9Y2W7 IL6ST Homo sapiens P40189
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 IL6ST Homo sapiens P40189
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 RPSA Homo sapiens P08865
Validated Y2H
32814053
Intra
KCNIP3 Q9Y2W7 RPSA Homo sapiens P08865
Y2H Array
32814053
Intra
KCNIP3 Q9Y2W7 RPSA Homo sapiens P08865
Y2H Pooling
32814053
Intra
KCNIP3 Q9Y2W7 GOLGA7 Homo sapiens Q7Z5G4
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 GOLGA7 Homo sapiens Q7Z5G4
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 IGF1R Homo sapiens P08069
Y2H Prey Pooling
25416956
Intra
KCNIP3 Q9Y2W7 CD177 Homo sapiens Q8N6Q3
Y2H Pooling
16189514
Intra
KCNIP3 Q9Y2W7 CD177 Homo sapiens Q8N6Q3
Y2H Prey Pooling
25416956
Intra
KCNIP3 Q9Y2W7 CD177 Homo sapiens Q8N6Q3
Validated Y2H
25416956
Intra
KCNIP3 Q9Y2W7 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Array
32296183
Intra
KCNIP3 Q9Y2W7 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Prey Pooling
32296183
Intra
KCNIP3 Q9Y2W7 MAVS Homo sapiens Q7Z434
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KCNIP3 Proteins

Cat. No. Product Name Accession Purity
HY-P75691 CSEN Protein, Human (His) Q9Y2W7-1 (M1-I256) ≥95%

Related Diseases

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DBA20

Rps15a-Related Diamond-Blackfan Anemia
Renal Artery Obstruction
Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07134 KCNIP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KCNIP3 VGNC VGNC:73834
Bos taurus KCNIP3 VGNC VGNC:102823
Canis familiaris KCNIP3 VGNC VGNC:42256
Mus musculus KCNIP3 MGD MGI:1929258
Rattus norvegicus KCNIP3 RGD RGD:70888
Felis catus KCNIP3 VGNC VGNC:63042
Others KCNIP3 NCBI