HMGN2 - high mobility group nucleosomal binding domain 2 Gene

Homo sapiens

Also known as HMG17

Gene ID: 3151 | Gene type: protein coding

About HMGN2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,472,440-26,476,642 (from NCBI)

This gene has 10 transcripts (splice variants), 126 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 279.3), lymph node (RPKM 141.8) and 25 other tissues.

Summary

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

HMGN2 Products(1)

mRNA	Protein	Name
NM_005517.4	NP_005508.1	non-histone chromosomal protein HMG-17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	16204630	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	16204630	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16204630	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16204630	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16204630	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGN2 Protein Structure

HMG14_17

0
90 a.a.

Protein Preferred Names

Protein Names

non-histone chromosomal protein HMG-17

high mobility group nucleosome-binding domain-containing protein 2

HMGN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HMGN2	P05204	PARP2	Homo sapiens	Q9UGN5	Anti Tag CoIP	33961781
Intra	HMGN2	P05204	TERF2	Homo sapiens	Q15554	Pull Down	21044950
Intra	HMGN2	P05204	TERF2	Homo sapiens	Q15554	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

HMGN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83094	HMGN2 Antibody (YA2839)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06244	HMGN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HMGN2	MGD	MGI:96136
Bos taurus	HMGN2	VGNC	VGNC:50536
Rattus norvegicus	HMGN2	RGD	RGD:620649

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