HOXB2 - homeobox B2 Gene

Homo sapiens

Also known as K8; HOX2; HOX2H; Hox-2.8

Gene ID: 3212 | Gene type: protein coding

About HOXB2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,542,655-48,545,109 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 42 paralogues. Broad expression in kidney (RPKM 11.3), fat (RPKM 6.5) and 19 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic Cancer. [provided by RefSeq, Jul 2008]

HOXB2 Products(1)

mRNA	Protein	Name
NM_002145.4	NP_002136.1	homeobox protein Hox-B2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15289435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12080061	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15289435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB2 Protein Structure

Homeobox

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-B2

K8 home protein

HOXB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXB2	P14652	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	HOXB2	P14652	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	32296183
Intra	HOXB2	P14652	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	HOXB2	P14652	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	HOXB2	P14652	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	HOXB2	P14652	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	HOXB2	P14652	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	35016035
Intra	HOXB2	P14652	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	HOXB2	P14652	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06306	HOXB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HOXB2	VGNC	VGNC:54955
Bos taurus	HOXB2	VGNC	VGNC:29918
Felis catus	HOXB2	VGNC	VGNC:99077
Mus musculus	HOXB2	MGD	MGI:96183
Rattus norvegicus	HOXB2	RGD	RGD:2319509

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