HOXB7 - homeobox B7 Gene

Homo sapiens

Also known as HOX2; HOX2C; HHO.C1; Hox-2.3

Gene ID: 3217 | Gene type: protein coding

About HOXB7

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,607,232-48,611,017 (from NCBI)

This gene has 3 transcripts (splice variants), 166 orthologues and 42 paralogues. Broad expression in kidney (RPKM 10.0), colon (RPKM 8.7) and 15 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

HOXB7 Products(1)

mRNA	Protein	Name
NM_004502.4	NP_004493.3	homeobox protein Hox-B7

HOXB7 Protein Structure

Homeobox

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-B7

homeo box 2C

HOXB7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXB7	P09629	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	HOXB7	P09629	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	HOXB7	P09629	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	HOXB7	P09629	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	HOXB7	P09629	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	HOXB7	P09629	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	HOXB7	P09629	PRKDC	Homo sapiens	P78527	Pull Down	17308091
Intra	HOXB7	P09629	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	17308091
Intra	HOXB7	P09629	XRCC5	Homo sapiens	P13010	Pull Down	17308091
Intra	HOXB7	P09629	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	17308091
Intra	HOXB7	P09629	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	HOXB7	P09629	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	HOXB7	P09629	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	HOXB7	P09629	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	HOXB7	P09629	CLK3	Homo sapiens	P49761	Y2H Array	25416956
Intra	HOXB7	P09629	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	HOXB7	P09629	CLK3	Homo sapiens	P49761	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Renal Hypoplasia

Bilateral Renal Aplasia

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5930	HOXB7 8–25		/	Unkown
HY-RS06311	HOXB7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOXB7	VGNC	VGNC:104621
Mus musculus	HOXB7	MGD	MGI:96188
Bos taurus	HOXB7	VGNC	VGNC:29921
Canis familiaris	HOXB7	VGNC	VGNC:41753
Rattus norvegicus	HOXB7	RGD	RGD:1559918
Felis catus	HOXB7	VGNC	VGNC:67624

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