2. Gene
  3. CLK3 - CDC like kinase 3 Gene

CLK3 - CDC like kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PHCLK3; PHCLK3/152

Gene ID: 1198 | Gene type: protein coding

About CLK3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,608,372-74,630,201 (from NCBI)

This gene has 27 transcripts (splice variants), 625 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 16.0), testis (RPKM 5.8) and 25 other tissues.

Summary

This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

CLK3 Products(2)

mRNA Protein Name
NM_001130028.2 NP_001123500.2 dual specificity protein kinase CLK3
NM_003992.5 NP_003983.2 dual specificity protein kinase CLK3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9637771 GOA
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
9637771 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9637771 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (304 - 620)

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  • 600
  • 638 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK3

CLK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CLK3 P49761 OAS2 Homo sapiens P29728
Y2H Array
25416956
Intra CLK3 P49761 OAS2 Homo sapiens P29728
Y2H Prey Pooling
25416956
Intra CLK3 P49761 OAS2 Homo sapiens P29728
Y2H Array
31515488
Intra CLK3 P49761 HOXB7 Homo sapiens P09629
Validated Y2H
25416956
Intra CLK3 P49761 HOXB7 Homo sapiens P09629
Y2H Prey Pooling
25416956
Intra CLK3 P49761 SUV39H1 Homo sapiens O43463
Y2H
23455924
Intra CLK3 P49761 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
23455924
Intra CLK3 P49761 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra CLK3 P49761 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra CLK3 P49761 SRSF10 Homo sapiens O75494
Anti Tag CoIP
33961781
Intra CLK3 P49761 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra CLK3 P49761 SRSF3 Homo sapiens P84103
Anti Tag CoIP
33961781
Intra CLK3 P49761 RNPS1 Homo sapiens Q15287
Anti Tag CoIP
33961781
Intra CLK3 P49761 RNPS1 Homo sapiens Q15287
Pull Down
32707033
Intra CLK3 P49761 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra CLK3 P49761 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra CLK3 P49761 SRPK2 Homo sapiens P78362
Pull Down
32707033
Intra CLK3 P49761 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra CLK3 P49761 TRA2B Homo sapiens P62995
Anti Tag CoIP
33961781
Intra CLK3 P49761 TRA2B Homo sapiens P62995
TAP
23602568
Intra CLK3 P49761 TRA2B Homo sapiens P62995
Pull Down
32707033
Intra CLK3 P49761 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra CLK3 P49761 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra CLK3 P49761 HOXB6 Homo sapiens P17509
Validated Y2H
25416956
Intra CLK3 P49761 RBMX Homo sapiens P38159
Y2H Prey Pooling
25416956
Intra CLK3 P49761 RBMX Homo sapiens P38159
Validated Y2H
25416956
Intra CLK3 P49761 ZNF263 Homo sapiens O14978
Validated Y2H
25416956
Intra CLK3 P49761 CLK2 Homo sapiens P49760
Validated Y2H
25416956
Intra CLK3 P49761 CLK2 Homo sapiens P49760
Y2H Array
25416956
Intra CLK3 P49761 RSRP1 Homo sapiens Q9BUV0
Y2H Array
25416956
Intra CLK3 P49761 RSRP1 Homo sapiens Q9BUV0
Validated Y2H
25416956
Intra CLK3 P49761 RSRP1 Homo sapiens Q9BUV0
Y2H Pooling
16189514
Intra CLK3 P49761 CLK2 Homo sapiens P49760
Anti Tag CoIP
33961781
Intra CLK3 P49761 CLK2 Homo sapiens P49760
Y2H
21516116
Intra CLK3 P49761 CLK2 Homo sapiens P49760
Y2H Prey Pooling
25416956
Intra CLK3 P49761 RSRP1 Homo sapiens Q9BUV0
Y2H Array
31515488
Intra CLK3 P49761 CLASRP Homo sapiens Q8N2M8
Pull Down
32707033
Intra CLK3 P49761 RBMY1A1 Homo sapiens P0DJD3
Y2H Prey Pooling
25416956
Intra CLK3 P49761 RBMY1A1 Homo sapiens P0DJD3
Y2H Array
25416956
Intra CLK3 P49761 RBMY1A1 Homo sapiens P0DJD3
Validated Y2H
25416956
Intra CLK3 P49761 RBMY1F Homo sapiens Q15415
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137443 Ipivivint Inhibitor 99.65% Phase 1
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-112296 T025 98.84% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-12828 KH-CB19 Inhibitor 99.31% Unkown
HY-103647 K00546 Inhibitor 98.08% Unkown
HY-117049 Leucettine L41 Inhibitor 98.70% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-RS02818 CLK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CLK3 VGNC VGNC:60964
Rattus norvegicus CLK3 RGD RGD:621259
Mus musculus CLK3 MGD MGI:1098670
Canis familiaris CLK3 VGNC VGNC:39348
Bos taurus CLK3 VGNC VGNC:27450
Macaca mulatta CLK3 VGNC VGNC:71260