2. Gene
  3. HPCAL1 - hippocalcin like 1 Gene

HPCAL1 - hippocalcin like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BDR1; HLP2; VILIP-3

Gene ID: 3241 | Gene type: protein coding

About HPCAL1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,302,904-10,427,604 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 14 paralogues. Ubiquitous expression in lung (RPKM 11.7), small intestine (RPKM 9.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]

HPCAL1 Products(5)

mRNA Protein Name
NM_001258357.2 NP_001245286.1 hippocalcin-like protein 1
NM_001258358.2 NP_001245287.1 hippocalcin-like protein 1
NM_001258359.2 NP_001245288.1 hippocalcin-like protein 1
NM_002149.4 NP_002140.2 hippocalcin-like protein 1
NM_134421.3 NP_602293.1 hippocalcin-like protein 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPCAL1 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (40 - 86)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

hippocalcin-like protein 1

calcium-binding protein BDR-1

HPCAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HPCAL1 P37235 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
HPCAL1 P37235 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
HPCAL1 P37235 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
HPCAL1 P37235 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
Intra
HPCAL1 P37235 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
HPCAL1 P37235 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
HPCAL1 P37235 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
HPCAL1 P37235 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
HPCAL1 P37235 COLGALT2 Homo sapiens Q8IYK4
Validated Y2H
32296183
Intra
HPCAL1 P37235 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra
HPCAL1 P37235 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra
HPCAL1 P37235 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra
HPCAL1 P37235 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
HPCAL1 P37235 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra
HPCAL1 P37235 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
HPCAL1 P37235 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
HPCAL1 P37235 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
HPCAL1 P37235 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
HPCAL1 P37235 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
HPCAL1 P37235 C19orf44 Homo sapiens Q9H6X5-2
Validated Y2H
32296183
Intra
HPCAL1 P37235 GATA5 Homo sapiens Q9BWX5
Validated Y2H
32296183
Intra
HPCAL1 P37235 NBL1 Homo sapiens P41271-2
Validated Y2H
32296183
Intra
HPCAL1 P37235 PLAAT2 Homo sapiens Q9NWW9
Validated Y2H
32296183
Intra
HPCAL1 P37235 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra
HPCAL1 P37235 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
HPCAL1 P37235 TPSG1 Homo sapiens Q9NRR2
Validated Y2H
32296183
Intra
HPCAL1 P37235 AMOT Homo sapiens A2BDD9
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 AMOT Homo sapiens A2BDD9
Y2H Array
32296183
Intra
HPCAL1 P37235 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
25416956
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
25416956
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra
HPCAL1 P37235 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
25416956
Intra
HPCAL1 P37235 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
HPCAL1 P37235 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
HPCAL1 P37235 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
HPCAL1 P37235 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
HPCAL1 P37235 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
HPCAL1 P37235 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Cross
HPCAL1 P37235 tir Escherichia coli O157:H7 Q7DB77
Lumier
25519916
Cross
HPCAL1 P37235 tir Escherichia coli O157:H7 Q7DB77
Y2H
25519916
Intra
HPCAL1 P37235 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra
HPCAL1 P37235 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
HPCAL1 P37235 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
HPCAL1 P37235 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra
HPCAL1 P37235 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
HPCAL1 P37235 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
HPCAL1 P37235 DTX2 Homo sapiens Q86UW9
Y2H Pooling
16189514
Intra
HPCAL1 P37235 HMG20A Homo sapiens Q9NP66
Y2H Pooling
16189514
Intra
HPCAL1 P37235 HMG20A Homo sapiens Q9NP66
Validated Y2H
25416956
Intra
HPCAL1 P37235 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra
HPCAL1 P37235 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
HPCAL1 P37235 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
HPCAL1 P37235 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
HPCAL1 P37235 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
HPCAL1 P37235 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
HPCAL1 P37235 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
HPCAL1 P37235 EPHB3 Homo sapiens P54753
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HPCAL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70346 HLP2/HPCAL1 Protein, Human (His) P37235 (M1-F193) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06334 HPCAL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HPCAL1 VGNC VGNC:67636
Macaca mulatta HPCAL1 VGNC VGNC:73510
Rattus norvegicus HPCAL1 RGD RGD:708375
Canis familiaris HPCAL1 VGNC VGNC:41768
Bos taurus HPCAL1 VGNC VGNC:29937
Mus musculus HPCAL1 MGD MGI:1855689
Others HPCAL1 NCBI