APLP1 - amyloid beta precursor like protein 1 Gene

Homo sapiens

Also known as APLP

Gene ID: 333 | Gene type: protein coding

About APLP1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,868,574-35,879,792 (from NCBI)

This gene has 12 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in brain (RPKM 172.7) and adrenal (RPKM 17.0).

Summary

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

APLP1 Products(2)

mRNA	Protein	Name
NM_001024807.3	NP_001019978.1	amyloid beta precursor like protein 1 isoform 1 precursor
NM_005166.5	NP_005157.1	amyloid beta precursor like protein 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-2A adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables alpha-2B adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables alpha-2C adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16193067	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to norepinephrine stimulus	IDA IDA: Inferred from direct assay	16531006	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16531006	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16531006	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16531006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APLP1 Protein Structure

APP_N

APP_Cu_bd

APP_E2

APP_amyloid

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names

Protein Names

amyloid beta precursor like protein 1

amyloid beta (A4) precursor-like protein 1

APLP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APLP1	P51693	APP	Homo sapiens	P05067-4	Anti Tag CoIP	16193067
Intra	APLP1	P51693	MED12	Homo sapiens	Q93074	Pull Down	21293490
Intra	APLP1	P51693	ZNF24	Homo sapiens	P17028	Anti Tag CoIP	16169070
Intra	APLP1	P51693	Tom1	Mus musculus	O88746	Anti Tag CoIP	14563850
Intra	APLP1	P51693	CNTN4	Homo sapiens	Q8IWV2	Pull Down	18272596
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	Anti Tag CoIP	16193067
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	X-Ray Diffraction	21930949
Intra	APLP1	P51693	CNTN5	Homo sapiens	O94779	Pull Down	18272596
Intra	APLP1	P51693	APLP2	Homo sapiens	Q06481	Anti Tag CoIP	16193067
Intra	APLP1	P51693	TSC22D1	Homo sapiens	Q15714	Y2H	21900206
Intra	APLP1	P51693	Slc5a7	Mus musculus	Q8BGY9	Anti Bait CoIP	17709753
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	Anti Bait CoIP	16193067

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APLP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7502	APLP-1 Protein, Human (171a.a, HEK293, His)	P51693 (G42-P212)	≥95%

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Brain Compression

Compression Of Brain

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00826	APLP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	APLP1	VGNC	VGNC:67755
Bos taurus	APLP1	VGNC	VGNC:26019
Mus musculus	APLP1	MGD	MGI:88046
Rattus norvegicus	APLP1	RGD	RGD:69257
Canis familiaris	APLP1	VGNC	VGNC:37988
Macaca mulatta	APLP1	VGNC	VGNC:69983

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